Human endometrium mRNA profile assessed by oligonucleotide three-dimensional microarray

Human endometrium mRNA profile assessed by oligonucleotide three-dimensional microarray

Author Otsuka, Audrey Y. Autor UNIFESP Google Scholar
Andrade, Priscila M. Google Scholar
Villanova, Fabiola Elizabeth Autor UNIFESP Google Scholar
Borra, Ricardo C. Google Scholar
Silva, Ismael Dale Cotrim Guerreiro da Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Univ Ibirapuera
Abstract Our purpose, in die present work, was to further comprehend the genetic events underlying the response to steroids of human endometrium from the mRNA as well as protein expression point of view. in order to achieve this goal we undertook 10 000-oligonucleotide, three-dimensional microarray analysis, followed by immunohistochemistry, on human normal endometrium in the proliferative and secretory phases of the menstrual cycle. the results revealed that a myriad of genes involved in immune response, calcium metabolism and thyroid hormone response were frequently overexpressed in the second or luteal phase of the menstrual cycle. During die follicular phase, in contrast, overexpression of genes was mainly restricted to those encoding proteins involved in cell proliferation.
Keywords microarray
human endometrium genes
menstrual cycle
Language English
Date 2007-09-01
Published in Gynecological Endocrinology. Lancaster: Parthenon Publishing Group, v. 23, n. 9, p. 527-534, 2007.
ISSN 0951-3590 (Sherpa/Romeo, impact factor)
Publisher Parthenon Publishing Group
Extent 527-534
Origin http://dx.doi.org/10.1080/09513590701550221
Access rights Closed access
Type Article
Web of Science ID WOS:000250859300007
URI http://repositorio.unifesp.br/handle/11600/30025

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