Gene analysis in patients with premature ovarian failure or gonadal dysgenesis: A preliminary study

Gene analysis in patients with premature ovarian failure or gonadal dysgenesis: A preliminary study

Author Massad-Costa, Ana Maria Google Scholar
Silva, Ismael Dale Cotrim Guerreiro da Google Scholar
Affonso, Regina Google Scholar
Soares, Jose Maria Google Scholar
Nunes, Marcia Gaspar Google Scholar
De Lima, Geraldo Rodrigues Google Scholar
Baracat, Edmund C. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Objective: the aim of this study was to evaluate the presence of mutations in the coding region of the QM gene and fragile X in patients with premature ovarian failure and gonadal dysgenesis.Methods: After approval by the local Ethics Committee, blood samples, in EDTA, of 100 normally ovulating women, 23 with premature ovarian failure (POF) and 14 with gonadal dysgenesis 46XX, aged less than 40 years, were screened for mutation in the QM gene coding region. All patients with POF have 46, XX karyotype and serum levels of foilicle-stimulating hormone (FSH) over 30 mIU/mL. in addition, all samples from patients with premature ovarian failure underwent analysis for fragile X.Results: the QM gene located at a hotspot region (Xq28) showed five points of mutations in a patient with premature ovarian failure. Four of them were able to change the amino acid sequence of the protein. None of our patients were diagnosed as having pre or mutant X fragile syndrome.Conclusion: Our study suggests that Xq28 (QM gene) may be involved in ovary failure. However, further studies are needed to confirm this hypothesis. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
Keywords gene analysis
premature ovarian failure
pure gonadal dysgenesis
QM gene
Language English
Date 2007-08-20
Published in Maturitas. Clare: Elsevier B.V., v. 57, n. 4, p. 399-404, 2007.
ISSN 0378-5122 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 399-404
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000248856900008

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