The G619A Aa-nat gene polymorphism does not contribute to sleep time variation in the brazilian population

The G619A Aa-nat gene polymorphism does not contribute to sleep time variation in the brazilian population

Author Silva Pereira, Danyella Google Scholar
Pedrazzoli, Mario Google Scholar
Del Vechio Koike, Bruna Google Scholar
Mazzili Louzada, Fernando Google Scholar
Benedito-Silva, Ana Amelia Google Scholar
Remesar Lopez, Alberto Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Fed Parana
Abstract Genes involved in melatonin synthesis, such as Aa-nat, may be important for our understanding of diurnal preference and circadian rhythm disturbances in humans. in Japan, Hohjoh et al. reported increased allelic frequencies of the 619A allele of the G619A Aa-nat gene polymorphism in a sample of Delayed Sleep Phase Syndrome (DSPS) patients. the present study sought to analyze G619A polymorphism frequency in a Brazilian sample, including DSPS patients. We found almost no allelic variation for G619A polymorphism in our sample, except for two heterozygous samples out of 551. Our results leave open the question of whether there would be an association if there were some genetic variation in our population. It is important to analyze different ethnic groups in order to validate the effect of G619A polymorphism on sleep timing.
Keywords melatonin
AA-NAT
DSPS
ethnicity
diurnal preference
polymorphism
Language English
Date 2007-07-01
Published in Behavior Genetics. New York: Springer, v. 37, n. 4, p. 637-638, 2007.
ISSN 0001-8244 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 637-638
Origin http://dx.doi.org/10.1007/s10519-007-9155-2
Access rights Closed access
Type Article
Web of Science ID WOS:000247412000011
URI http://repositorio.unifesp.br/handle/11600/29847

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