DNA damage and cellular death in oral mucosa cells of children who have undergone panoramic dental radiography

DNA damage and cellular death in oral mucosa cells of children who have undergone panoramic dental radiography

Author Angelieri, Fernanda Google Scholar
Oliveira, Gabriela R. de Google Scholar
Sannomiya, Eduardo K. Google Scholar
Ribeiro, Daniel A. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Background Despite wide use as a diagnostic tool in medical and dental practice, radiography can induce cytotoxic effects and genetic damage.Objective To evaluate DNA damage (micronucleus) and cellular death (pyknosis, karyolysis and karyorrhexis) in exfoliated buccal mucosa cells taken from healthy children following exposure to radiation during dental radiography.Materials and methods A total of 17 children who had undergone panoramic dental radiography were included.Results We found no statistically significant differences (P > 0.05) between micronucleated oral mucosa cells in children before and after exposure to radiation. On the other hand, radiation did cause other nuclear alterations closely related to cytotoxicity including karyorrhexis, pyknosis and karyolysis.Conclusion Taken together, these results indicate that panoramic dental radiography might not induce chromosomal damage, but may be cytotoxic. Overall, the results reinforce the importance of evaluating the health side effects of radiography and contribute to the micronucleus database, which will improve our understanding and practice of this methodology in children.
Keywords buccal mucosa cells
X-ray
children
Language English
Date 2007-06-01
Published in Pediatric Radiology. New York: Springer, v. 37, n. 6, p. 561-565, 2007.
ISSN 0301-0449 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 561-565
Origin http://dx.doi.org/10.1007/s00247-007-0478-1
Access rights Closed access
Type Article
Web of Science ID WOS:000246359500008
URI http://repositorio.unifesp.br/handle/11600/29784

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