Antihypertensive effect of a standardized aqueous extract of Cecropia glaziovii Sneth in rats: An in vivo approach to the hypotensive mechanism

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dc.contributor.author Lima-Landman, M. T. R.
dc.contributor.author Borges, A. C. R.
dc.contributor.author Cysneiros, Roberta Monterazzo [UNIFESP]
dc.contributor.author De Lima, T. C. M.
dc.contributor.author Souccar, C.
dc.contributor.author Lapa, A. J.
dc.date.accessioned 2016-01-24T13:48:39Z
dc.date.available 2016-01-24T13:48:39Z
dc.date.issued 2007-05-01
dc.identifier http://dx.doi.org/10.1016/j.phymed.2007.03.003
dc.identifier.citation Phytomedicine. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 14, n. 5, p. 314-320, 2007.
dc.identifier.issn 0944-7113
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/29713
dc.description.abstract Cecropia glaziovii Sneth is a common tree at the Southeastern Brazilian coast. As many other species of the genus, it shares the reputed folk use to treat heart failure, cough, asthma and bronchitis. the plant has been cultivated under controlled conditions and the 2% aqueous extract (AE) prepared with the dried leaves was standardized by its chemical contents on catechins, flavonoids and procyanidins. the present paper reports the antihypertensive activity of AE and of n-butanol fraction (BuF), an enriched semi-purified butanolic fraction used to isolate the main chemical constituents. Oral administration of AE and BuF induced hypotension in normotensive rats. the effect of AE (0.5 g/ kg/bi, p.o.) was time and dose-dependent peaking at 2-3 weeks after daily administration. BuF was faster but not more active than AE. Both extracts decreased the hypertension of spontaneous hypertensive rats, the hypertension induced in rats by L-NAME treatment and that induced by constriction of one renal artery. the antihypertensive effect was maintained for as long as 60 days of treatment and was reversible upon drug washout at the same rate of its establishment. Acute i.v. administration of BuF to anesthetized rats induced a fast short-lasting hypotension and inhibited the pressor responses to noradrenaline, angiotensin I and angiotensin II by 40%. These results were indirect indications that the hypotension induced by AE is not related to ACE inhibition, increased NO synthesis, or specific blockade of al and ATI receptors. It can be suggested that BuF interferes with the calcium handling mechanisms in smooth muscle cells and neurons. Intravenous injection of five out of nine compounds isolated from BuF produced immediate but short-lasting hypotension that does not correlate with the onset of the hypotension after oral treatment. This finding suggests that they may not be the compounds directly responsible for the delayed and sustained hypotension after per os administration of AE. the many compounds isolated from AE are under evaluation to determine its pharmacokinetics, mechanisms of action and interactions necessary to yield the plant effect. Although its mechanism is still unknown, AE seems to be an effective and safe anti hypertensive phytomedicine. (C) 2007 Elsevier GmbH. All rights reserved. en
dc.format.extent 314-320
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Phytomedicine
dc.rights Acesso restrito
dc.subject Cecropia glaziovii en
dc.subject medicinal plants en
dc.subject antihypertensive activity en
dc.subject phytomedicine en
dc.title Antihypertensive effect of a standardized aqueous extract of Cecropia glaziovii Sneth in rats: An in vivo approach to the hypotensive mechanism en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade Federal de Santa Catarina (UFSC)
dc.description.affiliation Universidade Federal de São Paulo, Nat Prod Sect, Dept Pharmacol, Escola Paulista Med, BR-04044020 São Paulo, Brazil
dc.description.affiliation Univ Fed Santa Catarina, Dept Pharmacol, Neuropharmacol Lab, Florianopolis, SC, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Nat Prod Sect, Dept Pharmacol, Escola Paulista Med, BR-04044020 São Paulo, Brazil
dc.identifier.doi 10.1016/j.phymed.2007.03.003
dc.description.source Web of Science
dc.identifier.wos WOS:000247200100003



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