Differential response related to genotoxicity between eggplant (Solanum melanogena) skin aqueous extract and its main purified anthocyanin (delphinidin) in vivo

Show simple item record

dc.contributor.author Azevedo, Luciana
dc.contributor.author Alves de Lima, Patricia L.
dc.contributor.author Gomes, Jose C.
dc.contributor.author Stringheta, Paulo C.
dc.contributor.author Ribeiro, Daniel A.
dc.contributor.author Salvadori, Daisy M. F.
dc.date.accessioned 2016-01-24T13:48:38Z
dc.date.available 2016-01-24T13:48:38Z
dc.date.issued 2007-05-01
dc.identifier http://dx.doi.org/10.1016/j.fct.2006.11.004
dc.identifier.citation Food and Chemical Toxicology. Oxford: Pergamon-Elsevier B.V., v. 45, n. 5, p. 852-858, 2007.
dc.identifier.issn 0278-6915
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/29701
dc.description.abstract Anthocyanins are the largest group of water-soluble pigments in the plant kingdom. A number of studies have demonstrated that anthocyanins present antioxidant capacity and show inhibitory effects on the growth of some cancer cells. Thus, the goal of this study was to evaluate both the antimutagenicity/antigenotoxicity and mutagenicity/genotoxicity of aqueous extract obtained from the Solanum melanogena, a possible novel source of anthocyanin, and its main purified anthocyanin extract (delphinidin), using the single cell (comet) assay and micronucleus test. Pretreatment with higher doses of the purified anthocyanin (10 and 20 mg/kg b.w.) led to a statistically significant reduction (p < 0.05) in the frequency of micronuclei in polychromatic erythrocytes induced by cyclophosphamide. the pattern of reduction ranged from 48% to 57% independent of concentration. No apparent: genotoxicity and mutagenicity was found for either the anthocyanin or delphinidin extracts. Taken together, these results suggest that mice pre-treated with specific compounds present in anthocyanins (delphinidin) displayed a lower incidence of mutations induced by cyclophosphamide. This finding emphasizes the potential of natural colorants to prevent mutations and also the applicability of genotoxic evaluation for improving health. Furthermore, the results presented here could be an additional argument to support the use of anthocyanins in the diet. (c) 2006 Published by Elsevier B.V. en
dc.format.extent 852-858
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Food and Chemical Toxicology
dc.rights Acesso restrito
dc.subject anthocyanins en
dc.subject single cell gel (comet) assay en
dc.subject micronucleus test en
dc.subject mice en
dc.subject antimutagenesis en
dc.title Differential response related to genotoxicity between eggplant (Solanum melanogena) skin aqueous extract and its main purified anthocyanin (delphinidin) in vivo en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Universidade Federal de Viçosa (UFV)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Estadual Paulista, Fac Med, Dept Patol, Botucatu, SP, Brazil
dc.description.affiliation Univ Fed Vicosa, Dept Ciencia & Tecnol Alimentos, Vicosa, MG, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Ciencias Saude, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Ciencias Saude, São Paulo, Brazil
dc.identifier.doi 10.1016/j.fct.2006.11.004
dc.description.source Web of Science
dc.identifier.wos WOS:000246213800017



File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search


Browse

Statistics

My Account