Differential response related to genotoxicity between eggplant (Solanum melanogena) skin aqueous extract and its main purified anthocyanin (delphinidin) in vivo

Differential response related to genotoxicity between eggplant (Solanum melanogena) skin aqueous extract and its main purified anthocyanin (delphinidin) in vivo

Author Azevedo, Luciana Google Scholar
Alves de Lima, Patricia L. Google Scholar
Gomes, Jose C. Google Scholar
Stringheta, Paulo C. Google Scholar
Ribeiro, Daniel A. Google Scholar
Salvadori, Daisy M. F. Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de Viçosa (UFV)
Universidade Federal de São Paulo (UNIFESP)
Abstract Anthocyanins are the largest group of water-soluble pigments in the plant kingdom. A number of studies have demonstrated that anthocyanins present antioxidant capacity and show inhibitory effects on the growth of some cancer cells. Thus, the goal of this study was to evaluate both the antimutagenicity/antigenotoxicity and mutagenicity/genotoxicity of aqueous extract obtained from the Solanum melanogena, a possible novel source of anthocyanin, and its main purified anthocyanin extract (delphinidin), using the single cell (comet) assay and micronucleus test. Pretreatment with higher doses of the purified anthocyanin (10 and 20 mg/kg b.w.) led to a statistically significant reduction (p < 0.05) in the frequency of micronuclei in polychromatic erythrocytes induced by cyclophosphamide. the pattern of reduction ranged from 48% to 57% independent of concentration. No apparent: genotoxicity and mutagenicity was found for either the anthocyanin or delphinidin extracts. Taken together, these results suggest that mice pre-treated with specific compounds present in anthocyanins (delphinidin) displayed a lower incidence of mutations induced by cyclophosphamide. This finding emphasizes the potential of natural colorants to prevent mutations and also the applicability of genotoxic evaluation for improving health. Furthermore, the results presented here could be an additional argument to support the use of anthocyanins in the diet. (c) 2006 Published by Elsevier B.V.
Keywords anthocyanins
single cell gel (comet) assay
micronucleus test
mice
antimutagenesis
Language English
Date 2007-05-01
Published in Food and Chemical Toxicology. Oxford: Pergamon-Elsevier B.V., v. 45, n. 5, p. 852-858, 2007.
ISSN 0278-6915 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 852-858
Origin http://dx.doi.org/10.1016/j.fct.2006.11.004
Access rights Closed access
Type Article
Web of Science ID WOS:000246213800017
URI http://repositorio.unifesp.br/handle/11600/29701

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