Study of blood porphyrin spectral profile for diagnosis of tumor progression

Study of blood porphyrin spectral profile for diagnosis of tumor progression

Author Courrol, Lilia Coronato Google Scholar
Silva, Flávia Rodrigues de Oliveira Google Scholar
Coutinho, Enia Lucia Google Scholar
Piccoli, Michelly Franca Google Scholar
Mansano, Ronaldo Domingues Google Scholar
Vieira Junior, Nilson Dias Google Scholar
Schor, Nestor Google Scholar
Bellini, Maria Helena Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
IPEN CNEN SP
Abstract Renal cell carcinoma (RCC) accounts for approximately 3% of new cancer incidence and mortality in the United States. Unfortunately many RCC masses remain asymptomatic and nonpalpable until they are advanced. Diagnosis and localization of early carcinoma play an important role in the prevention and curative treatment of RCC. the autofluorescence of blood porphyrin of healthy and tumor induced in male SCID mice was analyzed using fluorescence and excitation spectroscopy. A significant contrast between normal and tumor blood could be established. Blood porphyrin fluorophore showed enhanced fluorescence band (around 630 nm) in function of the tumor growth. This indicates that either the autofluorescence intensity of the blood fluorescence may provide a good parameter for the first approximation characterization of the tumor stage.
Keywords tumor
phorfyrin
fluorescence
tumor growth
Language English
Date 2007-05-01
Published in Journal of Fluorescence. New York: Springer/plenum Publishers, v. 17, n. 3, p. 289-292, 2007.
ISSN 1053-0509 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 289-292
Origin http://dx.doi.org/10.1007/s10895-007-0171-7
Access rights Closed access
Type Article
Web of Science ID WOS:000246183900006
URI http://repositorio.unifesp.br/handle/11600/29695

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