DNA damage in multiple organs after exposure to chlorhexidine in Wistar rats

DNA damage in multiple organs after exposure to chlorhexidine in Wistar rats

Author Grassi, Tony F. Google Scholar
Camargo, Elaine A. Google Scholar
Salvadori, Daisy M. F. Google Scholar
Marques, M. E. A. Google Scholar
Ribeiro, Daniel A. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Since chlorhexidine is effective against microorganisms, it is widely recommended in dentistry. However, studies have provided evidence that chlorhexidine is toxic for a variety of cell types. in order to identify potential genotoxins in different cell types, the purpose of this study was to investigate whether chlorhexidine digluconate is able to cause, in terms of DNA damage, alterations in leukocytes, liver, kidney and urinary bladder by the single cell gel (comet) assay. Ten male Wistar rats were divided into two groups: a negative control and the experimental group treated with 3 ml of 0.12% chlorhexidine digluconate by gavage once a day for 8 days. Statistically significant increases of DNA damage was observed in leukocytes and kidney cells of the chlorhexidine digluconate treated group as depicted by the mean tail moment. Taken together, the data indicate that leukocytes and kidney cells are potential targets for primary DNA damage following oral exposure to chlorhexidine digluconate as detected by single cell gel (comet) assay. (c) 2006 Elsevier GmbH. All rights reserved.
Keywords chlorhexidine
DNA damage
kidney
liver
single cell gel (comet) assay
urinary bladder
Language English
Date 2007-03-01
Published in International Journal of Hygiene and Environmental Health. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 210, n. 2, p. 163-167, 2007.
ISSN 1438-4639 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 163-167
Origin http://dx.doi.org/10.1016/j.ijheh.2006.09.001
Access rights Closed access
Type Article
Web of Science ID WOS:000244785400009
URI http://repositorio.unifesp.br/handle/11600/29551

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