Damage index assessment and quality of life in systemic lupus erythematosus patients (with long-term disease) in Northeastern Brazil

Damage index assessment and quality of life in systemic lupus erythematosus patients (with long-term disease) in Northeastern Brazil

Author Freire, Eutilia A. M. Google Scholar
Maia, Ines O. Google Scholar
Nepomuceno, Jamile C. A. Google Scholar
Ciconelli, Rozana M. Google Scholar
Institution Univ Fed Paraiba
Brazilian Soc Rheumatol
Universidade Federal de São Paulo (UNIFESP)
Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease that affects mainly young women. During the disease course, many organs and systems can suffer non-reversible damage that decreases both the patient's life span and also their quality of life. To determine the chronic damage and its correlation with quality of life, the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index was used in 63 patients who met the ACR criteria for SLE. Quality of life (QOL) was measured through the Medical Outcomes Survey short form 36 (SF-36), sociodemographic data were assessed using specific questionnaires, and disease activity was measured by the systemic lupus erythematosus disease activity index. Overall, 32% of the patients presented damage. Neuropsychiatric (25%) and vascular (20%) involvement were the most frequently related. Organic damages were associated with disease duration (p < 0.03). General health status and social aspects of quality of life were also associated with disease duration (p < 0.05 and p < 0.038, respectively). Socioeconomic status and disease activity were not associated with organic damages and quality of life. This study concluded that disease activity, cumulative damage, and quality of life had some influence in the overall view of lupus but those parameters are distinct domains of health status in SLE. Our analysis identified that disease duration had an important association with damage index and general health status.
Keywords damage index
quality of life
systemic lupus erythematosus
Language English
Date 2007-03-01
Published in Clinical Rheumatology. New York: Springer, v. 26, n. 3, p. 423-428, 2007.
ISSN 0770-3198 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 423-428
Origin http://dx.doi.org/10.1007/s10067-006-0517-6
Access rights Closed access
Type Article
Web of Science ID WOS:000243969700025
URI http://repositorio.unifesp.br/handle/11600/29536

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