Interferon-alpha therapy within the first year after acute hepatitis C infection in hernodialysis patients: efficacy and tolerance

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dc.contributor.author Rocha, Cristina M. [UNIFESP]
dc.contributor.author Perez, Renata M.
dc.contributor.author Narciso, Janaina L. [UNIFESP]
dc.contributor.author Ferreira, Adalgisa P. [UNIFESP]
dc.contributor.author Lemos, Lara B. [UNIFESP]
dc.contributor.author Medina-Pestana, Jose O. [UNIFESP]
dc.contributor.author Silva, Antonio Eduardo B. [UNIFESP]
dc.contributor.author Ferraz, Maria Lucia G. [UNIFESP]
dc.date.accessioned 2016-01-24T12:41:52Z
dc.date.available 2016-01-24T12:41:52Z
dc.date.issued 2007-02-01
dc.identifier http://dx.doi.org/10.1097/01.meg.0000252626.73172.f3
dc.identifier.citation European Journal of Gastroenterology & Hepatology. Philadelphia: Lippincott Williams & Wilkins, v. 19, n. 2, p. 119-123, 2007.
dc.identifier.issn 0954-691X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/29505
dc.description.abstract Background Interferon monotherapy significantly reduces the chronicity rate of acute hepatitis C in nonuremic patients. in this clinical study, we evaluated the efficacy and tolerance of interferon-alpha( therapy for acute hepatitis C in hemodialysis patients.Methods Patients with acute hepatitis C, established on the basis of seroconversion to anti-hepatitis C virus and the presence of hepatitis C virus RNA, received a low dose of interferon-alpha (3 MU three times per week) for 12 months or a high dose (5 MU three times per week, preceded by a daily induction dose) for 6 months. Response to treatment was defined as undetectable hepatitis C virus RNA at the end of treatment and sustained virological response was defined as persistent negative hepatitis C virus RNA 6 months after the end of treatment.Results Twenty-three patients were treated, 16 with a low dose of interferon-alpha and seven with a high dose. At the end of treatment, hepatitis C virus RNA was undetectable in 16/ 23 patients (70%). of these, 6/23 patients (26%) relapsed and 10/23 (43%) maintained a sustained virological response (38% in lower doses vs. 57% in higher doses). Treatment was well tolerated and only three patients discontinued therapy (13%).Conclusion Interferon-a within the first year after acute hepatitis C in hemodialysis patients was found to be safe and effective, inducing a sustained virological response in 43% of cases. This study supports the routine indication of acute hepatitis C treatment with interferon-alpha for hemodialysis patients, and higher doses administered for a shorter period of time should be tried according to the tolerance of the patients. en
dc.format.extent 119-123
dc.language.iso eng
dc.publisher Lippincott Williams & Wilkins
dc.relation.ispartof European Journal of Gastroenterology & Hepatology
dc.rights Acesso restrito
dc.subject acute hepatitis C en
dc.subject end-stage renal disease en
dc.subject hernodialysis en
dc.subject hepatitis C en
dc.subject interferon en
dc.subject side effects en
dc.title Interferon-alpha therapy within the first year after acute hepatitis C infection in hernodialysis patients: efficacy and tolerance en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade Federal do Rio de Janeiro (UFRJ)
dc.description.affiliation Universidade Federal de São Paulo, Div Gastroenterol, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Div Nephrol, São Paulo, Brazil
dc.description.affiliation Univ Fed Rio de Janeiro, Dept Internal Med, Rio de Janeiro, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Div Gastroenterol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Div Nephrol, São Paulo, Brazil
dc.identifier.doi 10.1097/01.meg.0000252626.73172.f3
dc.description.source Web of Science
dc.identifier.wos WOS:000254354700006



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