Analysis of colon tumors in rats by near-infrared Raman spectroscopy - art. no. 642714

Analysis of colon tumors in rats by near-infrared Raman spectroscopy - art. no. 642714

Author Duarte, Janaina Google Scholar
Hage, Raduan Google Scholar
Silveira, Landulfo Google Scholar
Silveira, Fabricio Google Scholar
Pacheco, Marcos Tadeu T. Google Scholar
Munin, Egberto Google Scholar
Plapler, Helio Google Scholar
Kessel, D. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Biomedical applications of near-infrared Raman spectroscopy have increased their importance at the last ten years. This technique can determinate the molecular composition of materials, allowing a sensible and fast biological diagnosis. It has showed to be a promising tool for health diagnosis due to its high sensibility. Colorectal cancer (CRC) is one of the most common malignant tumors in humans beings. in the last decades many experimental models have been developed in animals based in the use of chemical composites to induce the formation and development of these tumors, many of them present similar characteristics to those of natural occurrence aiming to the attainment of information on genesis, evolution, as well as diagnosis and more efficient therapies for treating these neoplasias. Amongst the most used chemical composites is the 1,2-dimetilhydrazine (DMH) because its morphological and histological similarity to those tumors. This study aims to compare in vivo normal colon tissue and tumoral colon tissue, induced by DMH, in rats by near-infrared Raman spectroscopy to permit the use in the near future for an efficient diagnosis in real time besides being useful as an auxiliary method for several therapies, including the photodynamic therapy.
Language English
Date 2007-01-01
Published in Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy Xvi. Bellingham: Spie-int Soc Optical Engineering, v. 6427, p. 42714-42714, 2007.
ISSN 0277-786X (Sherpa/Romeo, impact factor)
Publisher Spie-int Soc Optical Engineering
Extent 42714-42714
Access rights Closed access
Type Conference paper
Web of Science ID WOS:000246489700027

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