Effect of the C-terminus of murine S100A9 protein on experimental nociception

Effect of the C-terminus of murine S100A9 protein on experimental nociception

Author Dale, Camila Squarzoni Google Scholar
Pagano, Rosana de Lima Google Scholar
Paccola, Carina Cicconi Google Scholar
Pinotti-Guirao, Tatiana Google Scholar
Juliano, Maria Aparecida Google Scholar
Juliano, Luiz Google Scholar
Giorgi, Renata Google Scholar
Institution Butantan Inst
Universidade Federal de São Paulo (UNIFESP)
Abstract Calcium-binding protein S100A9 induces antinociception in mice evaluated by the writhing test. Similarly, a peptide identical to the C-terminus of murine S100A9 (mS100A9p) inhibits the hyperalgesia induced by jararhagin, a metalloprotease. Thus, we investigated the effect of mS100A9p on different models used to evaluate nociception. mS100A9p induced a dose-dependent inhibitory effect on the writhing test, and on mechanical hyperalgesia induced by carrageenan. mS100A9p inhibited thermal hyperalgesia induced by carrageenan. mS100A9p did not modify the nociceptive response in hot plate or tail-flick tests. These data demonstrate that the C-terminus of S100A9 protein interferes with control mechanisms of inflammatory pain. (c) 2006 Elsevier Inc. All rights reserved.
Keywords S100A9
nociception
hyperalgesia
carrageenan
inflammation
Language English
Date 2006-11-01
Published in Peptides. New York: Elsevier B.V., v. 27, n. 11, p. 2794-2802, 2006.
ISSN 0196-9781 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 2794-2802
Origin http://dx.doi.org/10.1016/j.peptides.2006.07.002
Access rights Closed access
Type Article
Web of Science ID WOS:000242318900033
URI http://repositorio.unifesp.br/handle/11600/29239

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