GABA and opioid binding distribution in the brain of the seizure-resistant Proechimys guyannensis: An autoradiography study

GABA and opioid binding distribution in the brain of the seizure-resistant Proechimys guyannensis: An autoradiography study

Author Rocha, Luisa Google Scholar
Arida, Ricardo Mario Google Scholar
Carvalho, Reinaldo de Amorim Google Scholar
Scorza, Fulvio Alexandre Google Scholar
Neri-Bazan, Leticia Google Scholar
Cavalheiro, Esper Abrao Google Scholar
Institution Ctr Res & Adv Studies
Universidade Federal de São Paulo (UNIFESP)
Abstract Proechimys guyannensis rodents present resistance to epilepsy. Autoradiography was used to map GABA(A) (H-3-Muscimol), benzodiazepine (H-3-Flunitrazepam), mu (H-3-DAMGO), and delta (H-3-DPDPE) opioid receptor binding in adult Proechimys guyannensis brain under normal conditions. Results were compared with values obtained from adult Wistar rats. Proechimys presented reduced 3H-Muscimol binding in several cortices, thalamus, medial amygdala nucleus, and dorsal dentate gyrus. H-3-Flunitrazepam binding was reduced in periaqueductal gray, frontal and entorhinal cortices, and enhanced in piriform cortex and ventral CA2 field of Ammons horn. Concerning H-3-DAMGO binding, high values were found in several cortices, medial amygdala nucleus, dorsal dentate gyrus, and periaqueductal gray, whereas reduced binding was detected in anterior olfactory tubercle, cingulated cortex, thalamus, basolateral amygdala, substantia nigra, and dorsal and ventral CA fields. High H-3-DPDPE binding was noticed in CA1 field from dorsal hippocampus, while reduced values were found in cingulate cortex, olfactory tubercle, thalamus, and substantia nigra. These findings provide the first description of receptor binding distribution of the Proechimys brain and suggest natural endogenous anticonvulsant mechanisms of theses rodents under normal conditions.
Keywords GABA(A)
benzodiazepine
mu-opioid receptors
delta-opioid receptor
Language English
Date 2006-10-01
Published in Synapse. Hoboken: Wiley-liss, v. 60, n. 5, p. 392-398, 2006.
ISSN 0887-4476 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 392-398
Origin http://dx.doi.org/10.1002/syn.20312
Access rights Closed access
Type Article
Web of Science ID WOS:000239755600006
URI http://repositorio.unifesp.br/handle/11600/29174

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