5,10-methylenetetrahydrofolate reductase polymorphisms and acute lymphoblastic leukemia risk: A meta-analysis

5,10-methylenetetrahydrofolate reductase polymorphisms and acute lymphoblastic leukemia risk: A meta-analysis

Author Pereira, Tiago da Veiga Autor UNIFESP Google Scholar
Rudnicki, Martina Google Scholar
Pereira, Alexandre Costa Google Scholar
Pombo-de-Oliveira, Maria S. Google Scholar
Franco, Rendrik Franca Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Inst Nacl Canc
Fleury Res Inst
Abstract There is evidence supporting a role for 5-10 methylenetetra-hydrofolate reductase (MTHFR) gene variants in acute lymphoblastic leukemia (ALL). To provide a more robust estimate of the effect of MTHFR polymorphisms on the risk of ALL, we did a meta-analysis to reevaluate the association between the two most commonly studied MTHFR polymorphisms (C677T and A1298C) and ALL risk. All case-control studies investigating an association between the C677T or A1298C polymorphisms and risk of ALL were included. We applied both fixed-effects and random-effects models to combine odds ratio (OR) and 95% confidence intervals (95% CI). Q-statistic was used to evaluate the homogeneity and both Egger and Begg-Mazumdar tests were used to assess publication bias. the meta-analysis of the C677T polymorphism and risk of childhood ALL included 13 studies with a total of 4,894 individuals. Under a fixed-effects model, the TT genotype failed to be associated with a statistically significant reduction of childhood ALL risk (TT versus CT + CC: OR, 0.88; 95% CI, 0.73-1.06; P = 0.18). However, individuals homozygous for the 677T allele exhibited a 2.2-fold decrease in risk of adult ALL (TT versus CT + CC: OR, 0.45; 95% CI, 0.26-0.77; P = 0.004). in both cases, no evidence of heterogeneity was observed. No association between the A1298C variant and susceptibility to both adult and childhood ALL was disclosed. Our findings support the proposal that the common genetic C677T polymorphism in the MTHFR contributes to the risk of adult ALL, but not to the childhood ALL susceptibility.
Language English
Date 2006-10-01
Published in Cancer Epidemiology Biomarkers & Prevention. Philadelphia: Amer Assoc Cancer Research, v. 15, n. 10, p. 1956-1963, 2006.
ISSN 1055-9965 (Sherpa/Romeo, impact factor)
Publisher Amer Assoc Cancer Research
Extent 1956-1963
Origin http://dx.doi.org/10.1158/1055-9965.EPI-06-0334
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000241616800032
URI http://repositorio.unifesp.br/handle/11600/29171

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