Can intraoperative electrocorticography patterns predict surgical outcome in patients with temporal lobe epilepsy secondary to unilateral mesial temporal sclerosis?

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dc.contributor.author Oliveira, Pedro A. L.
dc.contributor.author Garzon, Eliana [UNIFESP]
dc.contributor.author Caboclo, Luís Otávio Sales Ferreira [UNIFESP]
dc.contributor.author Sousa, Patricia da Silva [UNIFESP]
dc.contributor.author Carrete Junior, Henrique [UNIFESP]
dc.contributor.author Centeno, Ricardo Silva [UNIFESP]
dc.contributor.author Costa, José Maria P.
dc.contributor.author Machado, Helio Rubens
dc.contributor.author Yacubian, Elza Márcia Targas [UNIFESP]
dc.contributor.author Bianchin, Marino Muxfeldt
dc.contributor.author Sakamoto, Américo Ceiki [UNIFESP]
dc.date.accessioned 2016-01-24T12:41:29Z
dc.date.available 2016-01-24T12:41:29Z
dc.date.issued 2006-10-01
dc.identifier http://dx.doi.org/10.1016/j.seizure.2006.06.009
dc.identifier.citation Seizure-european Journal of Epilepsy. London: W B Saunders Co Ltd, v. 15, n. 7, p. 541-551, 2006.
dc.identifier.issn 1059-1311
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/29162
dc.description.abstract Introduction: Intraoperative electrocorticography (ECoG) can be performed in cases of temporal lobe epilepsy due to hippocampal sclerosis (TLE-HS). However, its significance and correlation with surgical outcome are still controversial.Objectives: To analyze the electrophysiological characteristics of temporal lobe structures during ECoG of patients with TLE-HS, with emphasis on the comparison between pre- and post-resection recordings and surgical outcome.Patients and methods: Seventeen patients with refractory TLE-HS submitted to corticoamigdalohipocampectomy were included in the study. Clinical variables included age at the onset, duration of epilepsy and seizure outcome. the postoperative follow-up ranged from 24 to 36 months. According to outcome subjects were divided in two subgroups: (A) individuals free of seizures (Engel 1A), and (B) individuals not-free of seizures (Engel 1B-IV). Four patterns of ECoG findings were identified: isolated discharges; high frequency spikes (HFS); continuous discharges; combination of isolated discharges and HFS. According to predominant topography ECoG was classified as mediobasal, lateral (or neocortical), mediobasal and lateral.Results: the progressive removal of the temporal pole and the hippocampus was associated with significant decrease of neocortical spikes. No correlation between clinical variables and seizure outcome was observed. Patients who only had isolated spikes on intraoperative ECoG presented a statistical trend for excellent surgical control. Patients who presented temporal pole blurring on MRI also had better post-surgical seizure outcome.Conclusions: This study showed that out of diverse clinical and laboratory variables, only isolated discharges on intraoperative ECoG and temporal pole blurring on MRI predicted excellent post-surgicat seizure outcome. However, other studies with larger number of patients are stilt necessary to confirm these findings. (C) 2006 British Epilepsy Association. Published by Elsevier B.V. All rights reserved. en
dc.format.extent 541-551
dc.language.iso eng
dc.publisher W B Saunders Co Ltd
dc.relation.ispartof Seizure-european Journal of Epilepsy
dc.rights Acesso aberto
dc.subject electrocorticography en
dc.subject temporal lobe epilepsy en
dc.subject hippocampus sclerosis en
dc.title Can intraoperative electrocorticography patterns predict surgical outcome in patients with temporal lobe epilepsy secondary to unilateral mesial temporal sclerosis? en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade de São Paulo (USP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Neurol & Neurosurg, Div Neurol, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Radiol, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Neurol & Neurosurg, Div Neurosurg, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Anesthesiol, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Ribeirao Preto Med Sch, Dept Surg, Div Neurosurg, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Ribeirao Preto Med Sch, Dept Neurol Psychiat & Clin Psychol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Neurol & Neurosurg, Div Neurol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Radiol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Neurol & Neurosurg, Div Neurosurg, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Anesthesiol, São Paulo, Brazil
dc.identifier.file WOS000240864700010.pdf
dc.identifier.doi 10.1016/j.seizure.2006.06.009
dc.description.source Web of Science
dc.identifier.wos WOS:000240864700010



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