Actinic cheilitis: histopathology and p53

Actinic cheilitis: histopathology and p53

Author Pimentel, Dalva Regina Neto Autor UNIFESP Google Scholar
Michalany, Nilceo Google Scholar
Alchorne, Maurício Mota de Avelar Autor UNIFESP Google Scholar
Abreu, Marilda Google Scholar
Borra, Ricardo Carneiro Google Scholar
Weckx, Luc Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Ibirapuera
Abstract Background: Chronic actinic cheilitis (AC) is a precursor of squamous cell carcinoma (SCC) of the lip.Objectives: To evaluate the histopathological characteristics that may help to identify AC more susceptible to carcinomatous transformation, to assess the p53 protein expression in AC, and to determine the value of the p53 expression as a marker of transformation into SCC of the lip.Methods: Seventy cases of chronic AC were reviewed, 31 of which were associated with SCCs. the samples were obtained from pathology reports of AC and SCC of the lip. Histopathology and immunohistochemical expression of the p53 protein were evaluated in isolated AC and in AC adjacent to SCC.Results: the intensity of the inflammatory infiltrate in the corium was the only histopathological finding significantly associated both with the presence of an invasive tumor and with the degree of epithelial atypia. Most AC (85%) were immunoreactive to the p53 protein. the p53 protein expression in cheilitis was not statistically associated with any other histopathological criteria.Conclusions: An intense inflammatory infiltrate in AC was predictive of an adjacent invasive SCC. in this study, the p53 protein immunoreactivity was not a marker of malignant transformation.
Language English
Date 2006-08-01
Published in Journal of Cutaneous Pathology. Oxford: Blackwell Publishing, v. 33, n. 8, p. 539-544, 2006.
ISSN 0303-6987 (Sherpa/Romeo, impact factor)
Publisher Blackwell Publishing
Extent 539-544
Origin http://dx.doi.org/10.1111/j.1600-0560.2006.00440.x
Access rights Closed access
Type Article
Web of Science ID WOS:000239635900002
URI http://repositorio.unifesp.br/handle/11600/29084

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