Update on the cefdinir spectrum and potency against pathogens isolated from uncomplicated skin and soft tissue infections in North America: are we evaluating the orally administered cephalosporins correctly?

Update on the cefdinir spectrum and potency against pathogens isolated from uncomplicated skin and soft tissue infections in North America: are we evaluating the orally administered cephalosporins correctly?

Author Jones, Ronald N. Google Scholar
Sader, Helio S. Google Scholar
Institution JMI Labs
Tufts Univ
Universidade Federal de São Paulo (UNIFESP)
Abstract The spectrum and potency of cefdinir, an orally administered cephalosporin, was reevaluated for the uncomplicated skin and soft tissue infection (uSSTI) indication using contemporary isolates from 2004 to 2005. Cefdinir continues to have high rates of susceptibility against methicillin-susceptible staphylococci (100.0%), beta-hemolytic streptococci (groups A and 13; 100.0%), viridans group streptococci (88.9%), Escherichia coli (93.2%), and Klebsiella pneumoniae (90.0%). No diminished activity was detected since the last evaluation (19972002 isolates), and cefdinir remains significantly more potent (4- to 16-fold) than cephalexin, even when using surrogate agents of cephalexin susceptibility that were suspect for over estimating true clinical utility. Activity greater than cephalexin (4-fold) was also noted for cefdinir against community-associated methicillin-resistant Staphylococcus aureus isolates. Cefdinir should be considered as a viable option for the therapy uSSTI caused by indicated species. (c) 2006 Elsevier Inc. All rights reserved.
Keywords cefdinir
cephalexin
uSSTI
CA-MRSA
resistance
reevaluation
cephalosporins
Language English
Date 2006-08-01
Published in Diagnostic Microbiology and Infectious Disease. New York: Elsevier B.V., v. 55, n. 4, p. 351-356, 2006.
ISSN 0732-8893 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 351-356
Origin http://dx.doi.org/10.1016/j.diagmicrobio.2006.04.015
Access rights Closed access
Type Article
Web of Science ID WOS:000239827300016
URI http://repositorio.unifesp.br/handle/11600/29068

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