Effects of a benzodiazepine on free recall of semantically related words

Effects of a benzodiazepine on free recall of semantically related words

Author Lemos Nogueira, Ana Maria Google Scholar
Pompeia, Sabine Google Scholar
Galduroz, Jose Carlos F. Google Scholar
Bueno, Orlando F. A. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Although it is widely known that benzodiazepines impair episodic memory, few studies have investigated their effects upon specific processes involved in free recall. This study evaluated the acute effects of flunitrazcpam (1.0 mg; 1.3 mg) and placebo in healthy volunteers on immediate and delayed free recall of word lists considering serial positions as well as semantic relations between words inserted in the middle of the lists (e.g. milk-cheese-butter). Flunitrazepam promoted a global amnestic effect, impairing recall in all serial positions except the last words (recency effect). Primacy and recency effects were preserved as indexed, respectively, by larger recall of the first and last words in relation to adjacent items. Facilitation in recall of semantically related words was not impaired by the drug when compared to recall in adjacent positions, in spite of a dose-dependent diminution of the number of words recalled also in mid-list positions. Flunitrazepam -induced deficits were interpreted as impairment in the formation of new associations between items, or groups of items in the case of related words, and context. Copyright (c) 2006 John Wiley & Sons, Ltd.
Keywords benzodiazepines
episodic memory
semantic facilitation
serial position curve
Language English
Date 2006-07-01
Published in Human Psychopharmacology-clinical and Experimental. Chichester: John Wiley & Sons Ltd, v. 21, n. 5, p. 327-336, 2006.
ISSN 0885-6222 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 327-336
Origin http://dx.doi.org/10.1002/hup.775
Access rights Closed access
Type Article
Web of Science ID WOS:000239669400006
URI http://repositorio.unifesp.br/handle/11600/28998

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