Central nervous system paracoccidioidomycosis: analysis os 13 cases

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dc.contributor.author Fagundes-Pereyra, Walter J. [UNIFESP]
dc.contributor.author Carvalho, Gervasio Teles Cardoso
dc.contributor.author Góes, Alfredo de Miranda
dc.contributor.author Silva, Francisco das Chagas Lima e
dc.contributor.author Sousa, Atos Alves de
dc.date.accessioned 2016-01-24T12:41:12Z
dc.date.available 2016-01-24T12:41:12Z
dc.date.issued 2006-06-01
dc.identifier http://dx.doi.org/10.1590/S0004-282X2006000200018
dc.identifier.citation Arquivos de Neuro-psiquiatria. São Paulo, SP: Assoc Arquivos de Neuro- Psiquiatria, v. 64, n. 2A, p. 269-276, 2006.
dc.identifier.issn 0004-282X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/28933
dc.description.abstract Paracoccidioidomycosis (PCM) is a systemic granulomatous disease caused by Paracoccidioides brasiliensis, prevalent in Latin America, particularly in Brazil. Central nervous system (CNS) involvement occur in about 10% of cases. Thirteen patients with PCM involving CNS were studied considering clinical manifestation, neuroradiology and treatment modalities. Age ranged from 30 to 71 years-old (M=47.1 +/- 11.6 Me=46). There were eleven men and two women. the most frequent symptoms were motor deficits (53.8%), cognitive disturbance (53.8%), weight loss (46.1%), headaches (46.1%) and seizures (46.1%). the diagnosis was confirmed by the demonstration of P. brasiliensis. Granulomatous forms were present in all patients. Four (30.8%) of them had also meningeal involvement (mixed form). Computerized tomography (CT) scans were obtained in all cases and magnetic resonance imaging (MRI) was used in one case. Serology for HIV was done in ten patients (76.9%), and all the tests were negatives. Amphotericin B was used in twelve patients (92.3%), one of them by intraventricular infusion. in eight patients (61.5%), trimethopim and sulfamethoxazole were used, and, in two (15.4%), sulfadiazine and pirimetamine. Fluconazole, ketoconazole and itraconazole were each one used in a different patient as well. Six patients died (46.1%) and seven (53.9%) had satisfatory outcome. the follow-up period ranged from 2 to 74 (M=30.9) months. in conclusion, the CNS involvement in paracoccidioidomycosis is more frequent and more serious than thought before. the clinical manifestations, CT scans and MRI findings are not specific of paracoccidioidomycosis. en
dc.format.extent 269-276
dc.language.iso eng
dc.publisher Assoc Arquivos de Neuro- Psiquiatria
dc.relation.ispartof Arquivos de Neuro-psiquiatria
dc.rights Acesso aberto
dc.subject paracoccidioidomycosis en
dc.subject central nervous system en
dc.subject Paracoccidioides brasiliensis en
dc.title Central nervous system paracoccidioidomycosis: analysis os 13 cases en
dc.title Paracoccidioidomicose do sistema nervoso central: análise de 13 casos pt
dc.type Artigo
dc.contributor.institution Clin Neurol & Neurocirurgia Santa Casa Belo Horiz
dc.contributor.institution Mestre Med Santa Casa Belo Horizonte
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Serv Neurocirurg Santa Casa
dc.contributor.institution Universidade Federal de Minas Gerais (UFMG)
dc.contributor.institution Programa Pos Grad Santa Casa
dc.description.affiliation Clin Neurol & Neurocirurgia Santa Casa Belo Horiz, Belo Horizonte, MG, Brazil
dc.description.affiliation Mestre Med Santa Casa Belo Horizonte, Belo Horizonte, MG, Brazil
dc.description.affiliation UNIFESP, Escola Paulista Med, São Paulo, Brazil
dc.description.affiliation Serv Neurocirurg Santa Casa, Belo Horizonte, MG, Brazil
dc.description.affiliation Univ Fed Minas Gerais, Dept Bioquim & Imunol, Inst Ciencias Biol, Belo Horizonte, MG, Brazil
dc.description.affiliation Programa Pos Grad Santa Casa, Belo Horizonte, MG, Brazil
dc.description.affiliationUnifesp UNIFESP, Escola Paulista Med, São Paulo, Brazil
dc.identifier.file S0004-282X2006000200018.pdf
dc.identifier.scielo S0004-282X2006000200018
dc.identifier.doi 10.1590/S0004-282X2006000200018
dc.description.source Web of Science
dc.identifier.wos WOS:000238113200018



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