Cerebrospinal fluid GABA levels in chronic migraine with and without depression

Cerebrospinal fluid GABA levels in chronic migraine with and without depression

Author Vieira, DSS Google Scholar
Naffah-Mazacoratti, M. G. Google Scholar
Zukerman, E. Google Scholar
Soares, CAS Google Scholar
Alonso, E. O. Google Scholar
Faulhaber, MHW Google Scholar
Cavalheiro, E. A. Google Scholar
Peres, MFP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Psychiatric comorbidity is one of the key elements in chronic migraine (CM) management. Depression is particularly common in these patients, occurring in up to 85%. Preclinical studies have suggested that gamma-aminobutyric acid (GABA) levels may be decreased in animal models of depression. Also, clinical studies have reported low level in mood disorder patients for both plasma and cerebrospinal fluid (CSF) GABA. We hypothesized that low GABA levels in the brain might be related to the depression associated with CM. We studied 14 chronic migraine patients, with or without depression, compared to age-and sex-matched controls. CSF GABA levels were measured by HPLC. CSF GABA levels showed significant lower levels in depressed patients than those without depression. No difference was found when comparing patients versus controls. A GABA deficiency may be the underlying mechanism of depression in CM. Hence, preventive therapies modulating GABA neurotransmission could be used in CM associated with depression. (c) 2006 Elsevier B.V. All rights reserved.
Keywords chronic migraine
depression
GABA
pathophysiology
cerebrospinal fluid
Language English
Date 2006-05-23
Published in Brain Research. Amsterdam: Elsevier B.V., v. 1090, p. 197-201, 2006.
ISSN 0006-8993 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 197-201
Origin http://dx.doi.org/10.1016/j.brainres.2006.03.051
Access rights Closed access
Type Article
Web of Science ID WOS:000238628700023
URI http://repositorio.unifesp.br/handle/11600/28912

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