Chronic unpredictable stress exacerbates lipopolysaccharide-induced activation of nuclear factor-kappa B in the frontal cortex and hippocampus via glucocorticoid secretion

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dc.contributor.author Munhoz, Carolina Demarchi
dc.contributor.author Lepsch, Lucilia B.
dc.contributor.author Kawamoto, Elisa Mitiko
dc.contributor.author Malta, Marília Brinati
dc.contributor.author Lima, Larissa de Sá
dc.contributor.author Avellar, Maria Cristina Werneck [UNIFESP]
dc.contributor.author Sapolsky, Robert M.
dc.contributor.author Scavone, Cristoforo
dc.date.accessioned 2016-01-24T12:41:06Z
dc.date.available 2016-01-24T12:41:06Z
dc.date.issued 2006-04-05
dc.identifier http://dx.doi.org/10.1523/JNEUROSCI.4398-05.2006
dc.identifier.citation Journal of Neuroscience. Washington: Soc Neuroscience, v. 26, n. 14, p. 3813-3820, 2006.
dc.identifier.issn 0270-6474
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/28843
dc.description.abstract Although the anti-inflammatory actions of glucocorticoids (GCs) are well established in the periphery, these stress hormones can increase inflammation under some circumstances in the brain. the transcription factor nuclear factor-kappa B (NF-kappa B), which is inhibited by GCs, regulates numerous genes central to inflammation. in this study, the effects of stress, GCs, and NMDA receptors on lipopolysaccharide (LPS)-induced activation of NF-kappa B in the brain were investigated. One day after chronic unpredictable stress (CUS), nonstressed and CUS rats were treated with saline or LPS and killed 2 h later. CUS potentiated the increase in LPS-induced activation of NF-kappa B in frontal cortex and hippocampus but not in the hypothalamus. This stress effect was blocked by pretreatment of rats with RU-486, an antagonist of the GC receptor. MK-801 [(+)-5-methyl-10,11-dihydro-5H-dibenzo [a,d] cyclohepten-5,10-imine maleate], an NMDA receptor antagonist, also reduced the effect of LPS in all three brain regions. However, the combined antagonism of both GC and NMDA receptors produced no further reduction in NF-kappa B activation when compared with the effect of each treatment alone. Our results indicate that stress, via GC secretion, can increase LPS-induced NF-kappa B activation in the frontal cortex and hippocampus, agreeing with a growing literature demonstrating proinflammatory effects of GCs. en
dc.format.extent 3813-3820
dc.language.iso eng
dc.publisher Soc Neuroscience
dc.relation.ispartof Journal of Neuroscience
dc.rights Acesso aberto
dc.subject glucocorticoids en
dc.subject chronic stress en
dc.subject NF-kappa B en
dc.subject LPS en
dc.subject NMDA en
dc.subject brain en
dc.title Chronic unpredictable stress exacerbates lipopolysaccharide-induced activation of nuclear factor-kappa B in the frontal cortex and hippocampus via glucocorticoid secretion en
dc.type Artigo
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Stanford Univ
dc.description.affiliation Univ São Paulo, Inst Biomed Sci, Dept Pharmacol, BR-05508900 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Dept Pharmacol, Sect Expt Endocrinol, BR-04044020 São Paulo, Brazil
dc.description.affiliation Stanford Univ, Dept Biol Sci, Stanford, CA 94305 USA
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Dept Pharmacol, Sect Expt Endocrinol, BR-04044020 São Paulo, Brazil
dc.identifier.doi 10.1523/JNEUROSCI.4398-05.2006
dc.description.source Web of Science
dc.identifier.wos WOS:000236552400023



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