Phytate technetium-99m versus dextran 500 technetium-99m in the sentinel lymph node biopsy

Phytate technetium-99m versus dextran 500 technetium-99m in the sentinel lymph node biopsy

Author Paiva, G. R. Google Scholar
Filho, RSO Google Scholar
Ferreira, L. M. Google Scholar
Wagner, J. Google Scholar
Nogueira, WSA Google Scholar
Novo, N. F. Google Scholar
Juliano, Y. Google Scholar
Rocha, JLBS Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Hosp Israelita Albert Einstein
Univ Santo Amaro
Univ Fec Rondonia
Abstract Purpose: To study which of the two most used radiopharmaceutical drugs for the sentinel lymph node (SLN) biopsy procedure (dextran 500 Tc-99m and phytate Tc-99m) best defines the SLN and migrates less to other lymph nodes.Material and Methods: Thirty-two rats, separated into two groups, underwent lymphoscintigraphy examination with either dextran or phytate followed by sentinel (popliteal), lumbar, and inguinal lymph node biopsy. Radiation was detected with a gamma probe.Results: the statistical study indicated count rates significantly higher in the SLN than in the other basins for both the dextran (P < 0.01) and phytate groups (P < 0.001). There was no statistically significant difference concerning SLN absorption in either group (P=0.2981). in the dextran group, migration occurred to 1.5 lymphatic basins with counting higher than 10% of that found in the SLN versus 0.8 in the phytate group (P=0.0023). Migration was thus higher in the dextran group (P=0.0207).Conclusion: There was no statistically significant difference between dextran and phytate in the SLN identification, but the phytate migrated to fewer lymphatic basins beyond the SLN and with less intensity.
Keywords biopsy procedures
dextran 500 technetium-99m
phytate technetium-99m
sentinel lymph node
Language English
Date 2006-02-01
Published in Acta Radiologica. Abingdon: Taylor & Francis Ltd, v. 47, n. 1, p. 65-70, 2006.
ISSN 0284-1851 (Sherpa/Romeo, impact factor)
Publisher Taylor & Francis Ltd
Extent 65-70
Access rights Closed access
Type Article
Web of Science ID WOS:000235289600012

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