The Ala45Thr polymorphism of NEUROD1 is associated with type 1 diabetes in Brazilian women

The Ala45Thr polymorphism of NEUROD1 is associated with type 1 diabetes in Brazilian women

Author Oliveira, CSV Google Scholar
Hauache, O. M. Google Scholar
Vieira, JGH Google Scholar
Maciel, RMB Google Scholar
Sjoroos, M. Google Scholar
Canani, L. H. Google Scholar
Velho, G. Google Scholar
Gross, J. L. Google Scholar
Reis, A. F. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Fleury Inst
Wallac Oy
Hosp Clin Porto Alegre
Univ Fed Rio Grande Sul
INSERM
Abstract Background: NEUROD1 encodes a transcription factor expressed in the endocrine pancreas, and involved in beta-cell development, function and mechanisms of apoptosis. in this study, we investigated the association of a frequent polymorphism in exon 2 of NEUROD1 (G > A; Ala45Thr) with Type 1 diabetes in Brazilian subjects.Methods: A population/association study comprising 246 unrelated Type 1 diabetic and 275 nondiabetic white Brazilian subjects. the Ala45Thr variant was genotyped by a PCR-RFLP method.Results: the frequency of the Thr allele was significantly higher in patients with Type 1 diabetes than in controls (42.3% vs 35.3%, P = 0.02). Stratification by gender showed that homozygosity for the Thr allele was associated with Type 1 diabetes in women with odds ratio of 3.66 (95 % C.I. 1.43-10.11, P = 0.009) as compared to homozygosity for the Ala allele. This effect was not observed in men.Conclusions: We found a gender-specific association of the Ala45Thr variant of NEUROD1 with Type 1 diabetes in Brazilian women. Our results suggest that gender as well as ethnicity might modulate the association of NEUROD1 with Type 1 diabetes.
Keywords Type 1 diabetes mellitus
genetics
NEUROD1/BETA2 gene
association study
Language English
Date 2005-12-01
Published in Diabetes & Metabolism. Moulineaux Cedex 9: Masson Editeur, v. 31, n. 6, p. 599-602, 2005.
ISSN 1262-3636 (Sherpa/Romeo, impact factor)
Publisher Masson Editeur
Extent 599-602
Origin http://dx.doi.org/10.1016/S1262-3636(07)70237-9
Access rights Closed access
Type Article
Web of Science ID WOS:000234215500013
URI http://repositorio.unifesp.br/handle/11600/28585

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