Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats

Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats

Author Hoexter, Marcelo Queiroz Autor UNIFESP Google Scholar
Rosa, Pedro S. Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Mello, Luiz Eugenio Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Purpose: To investigate the consequences of caffeine consumption on epileptic seizures, we used the pilocarpine and the kainate models of epilepsy. We hypothesized that prolonged caffeine consumption or its withdrawal would alter adenosine levels and hence alter seizure susceptibility.Methods: We administered a 0.1% caffeine solution in the drinking water of adult male Wistar rats over a 2-week period. We challenged another group of animals with the same doses of pilocarpine or kainate 12 h after the withdrawal of the same caffeine-administration protocol.Results: This did not alter the threshold for the induction of seizures by a subconvulsant dose of pilocarpine (200 mg/kg, i.p.) or kainic acid (8 mg/kg, i.p.). Similarly, challenging another group of animals with the same doses of pilocarpine or kainate 12 h after the withdrawal of the same caffeine-administration protocol did not lead to any significant changes in seizures.Conclusions: With the pilocarpine model of epilepsy, we were not able to find any significant difference in seizure profile that could stem from either caffeine administration or its withdrawal. Despite the extensive laboratory evidence on the convulsant properties of xanthine derivatives in animal models of epilepsy, such strong evidence is lacking in clinical settings. Our current findings with the administration of caffeine at doses similar to those of daily life both support and confirm the clinical experience.
Keywords status epilepticus
xanthines
adenosine
anticonvulsant
spontaneous seizures
coffee
Language English
Date 2005-09-01
Published in Epilepsia. Oxford: Blackwell Publishing, v. 46, n. 9, p. 1401-1406, 2005.
ISSN 0013-9580 (Sherpa/Romeo, impact factor)
Publisher Blackwell Publishing
Extent 1401-1406
Origin http://dx.doi.org/10.1111/j.1528-1167.2005.63904.x
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000231507100006
URI http://repositorio.unifesp.br/handle/11600/28433

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account