Use of interferon alpha in intratumoral chemotherapy for cystic craniopharyngioma

Use of interferon alpha in intratumoral chemotherapy for cystic craniopharyngioma

Author Cavalheiro, Sergio Google Scholar
Dastoli, Patricia A. Google Scholar
Silva, Nasjla Saba Google Scholar
Toledo, Silvia Regina Caminada de Autor UNIFESP Google Scholar
Lederman, Henrique Google Scholar
Silva, M. C. da Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objectives: This study analyzed the intratumoral activity of interferon alpha (IFN-alpha) in the treatment of cystic craniopharyngiomas. Patients and methods: From January 2000 to January 2004, nine patients presenting with cystic craniopharyngiomas were treated with intratumoral injection of IFN-alpha at the Pediatric Oncology Institute of the Federal University of São Paulo-Escola Paulista de Medicina. Age ranged from 1 year and 10 months to 18 years (mean 10 years). All intratumoral catheters were inserted by a subfrontal approach. Doses varied from 36 to 108 MU. Results: There was complete disappearance of the lesion in seven cases. in two cases, partial reduction of tumor size was observed at follow-up. Follow-up varied from 1 year to 3 years and 6 months (mean 1 year 8 months). Conclusions: IFN-alpha proved to be an effective drug in the control of cystic craniopharyngiomas. Additional studies should be carried out to determine the optimal dose of IFN-alpha in the treatment of cystic craniopharyngioma. in addition, other drugs possessing high efficacy and low neurotoxicity should be analyzed.
Keywords interferon alpha
intratumoral
bleomycin
cystic craniopharyngioma
apoptosis
Ommaya reservoir
Language English
Date 2005-08-01
Published in Childs Nervous System. New York: Springer, v. 21, n. 8-9, p. 719-724, 2005.
ISSN 0256-7040 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 719-724
Origin http://dx.doi.org/10.1007/s00381-005-1226-1
Access rights Closed access
Type Article
Web of Science ID WOS:000231511300016
URI http://repositorio.unifesp.br/handle/11600/28398

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