Characterization of CD28, CTLA4, and ICOS polymorphisms in three Brazilian ethnic groups

Characterization of CD28, CTLA4, and ICOS polymorphisms in three Brazilian ethnic groups

Author Guzman, V. B. Google Scholar
Morgun, A. Google Scholar
Shulzhenko, N. Google Scholar
Mine, K. L. Google Scholar
Goncalves-Primo, A. Google Scholar
Musatti, C. C. Google Scholar
Gerbase-Delima, M. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Costimulatory molecules CD28, CTLA-4 (cytotoxic T-lymphocyte-associated antigen-4), and ICOS (inducible costimulator) genes lie within the 300-kb chromosome region 2q33. CD28, CTLA-4, and ICOS have been described to be important regulators of T-cell activation. With the objective to Study ethnic variations in allelic frequencies and linkage disequilibrium (LD) patterns, we genotyped CD28 intron 3 (+17 T > C), CTLA4 promoter (-319 C > T), CTLA4 exon 1 (+49 A > G), and ICOS 3' UTR (1564 T > C) polymorphisms in white (n = 103), mulatto (n = 97), and black (n = 79) Brazilian healthy individuals. No significant deviations from Hardy-Weinberg equilibrium were found in any of the population samples. A higher frequency of CD28 +17 C allele was detected in white (27%) in comparison with mulatto (15%) and black (13%) (p = 0.005) populations. LD between CD28 +17 C and CTLA4 -319 T alleles was observed in whites (p < 0.0001), mulattos (p = 0.0001), and blacks (p = 0.0002).
Keywords CD28
ICOS
CTLA4
gene polymerphisms
linkage disequilibrium
Language English
Date 2005-07-01
Published in Human Immunology. New York: Elsevier B.V., v. 66, n. 7, p. 773-776, 2005.
ISSN 0198-8859 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 773-776
Origin http://dx.doi.org/10.1016/j.humimm.2005.04.007
Access rights Closed access
Type Article
Web of Science ID WOS:000231987600003
URI http://repositorio.unifesp.br/handle/11600/28373

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