Effects of gabaergic drugs on reserpine-induced oral dyskinesia

Effects of gabaergic drugs on reserpine-induced oral dyskinesia

Author Peixoto, M. R. Google Scholar
Araujo, N. P. Google Scholar
Silva, R. H. Google Scholar
Castro, JPMV Google Scholar
Fukushiro, D. F. Google Scholar
Faria, R. R. Google Scholar
Zanier-Gomes, P. H. Google Scholar
Medrano, W. A. Google Scholar
Frussa-Filho, R. Google Scholar
Abilio, V. C. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Recently we have described the antidyskinetic property of the GABA mimetic drugs valproic acid and topiramate on reserpine-induced oral dyskinesia. in this respect, oral dyskinesia has been associated with important neuropathologies. the present study investigates the effects of different doses of the GABA(A) agonist tetrahydroisoxazolopyridine (THIP), of the GABA(B) agonist baclofen as well as of the GABAA modulator diazepam on the manifestation of reserpine-induced orofacial dyskinesia. Male Wistar rats received two injections of vehicle or of 1 mg/kg reserpine separated by 48 h. Twenty-four hours later, animals were acutely treated with vehicle or THIP (2, 4 or 8 mg/kg), baclofen (1, 2 or 4 mg/kg) or diazepam (1, 2 or 4 mg/kg) and were observed for quantification of oral dyskinesia and open-field general activity. in order to verify the effects of these drugs per se on spontaneous oral movements, male Wistar rats were acutely treated with vehicle, 8 mg/kg THIP, 4 mg/kg baclofen or 4 mg/kg diazepam and observed for quantification of oral dyskinesia. the two highest doses of THIP or of baclofen abolished the manifestation of reserpine-induced oral dyskinesia while the lowest dose of baclofen attenuated it. Diazepam did not modify reserpine-induced oral dyskinesia at any dose tested. the highest doses of these drugs did not modify spontaneous oral movements. Reserpineinduced decrease in open-field general activity was not modified by any of the doses of THIP and diazepam or by the two lowest doses of baclofen. the highest dose of baclofen potentiated the increase in the duration of immobility induced by reserpine. These results reinforce the involvement of GABAergic hypofunction in the expression of oral dyskinesias, and support the potential therapeutic use of THIP and baclofen in the treatment of oral dyskinesias. © 2004 Elsevier B.V. All rights reserved.
Keywords GABA
oral dyskinesia
baclofen
THIP
diazepam
reserpine
rats
Language English
Date 2005-05-07
Published in Behavioural Brain Research. Amsterdam: Elsevier B.V., v. 160, n. 1, p. 51-59, 2005.
ISSN 0166-4328 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 51-59
Origin http://dx.doi.org/10.1016/j.bbr.2004.11.014
Access rights Closed access
Type Article
Web of Science ID WOS:000228888400006
URI http://repositorio.unifesp.br/handle/11600/28300

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