Association of the apolipoprotein A-IV : 360 Gln/His polymorphism with cerebrovascular disease, obesity, and depression in a Brazilian elderly population

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dc.contributor.author Ejchel, Tatiana Flank [UNIFESP]
dc.contributor.author Araujo, LMQ
dc.contributor.author Ramos, L. R.
dc.contributor.author Cendoroglo, M. S.
dc.contributor.author Smith, MDC
dc.date.accessioned 2016-01-24T12:37:51Z
dc.date.available 2016-01-24T12:37:51Z
dc.date.issued 2005-05-05
dc.identifier http://dx.doi.org/10.1002/ajmg.b.30175
dc.identifier.citation American Journal of Medical Genetics Part B-neuropsychiatric Genetics. Hoboken: Wiley-liss, v. 135B, n. 1, p. 65-68, 2005.
dc.identifier.issn 1552-4841
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/28298
dc.description.abstract The identification of genetic polymorphisms as risk factors for complex diseases can be relevant for their prevention, diagnosis, and prognosis. the apolipoprotein A-IV: 360 Gln/His polymorphism was investigated in 383 elderly individuals, who were participants of a longitudinal study commenced in 1991. the major morbidities that affect elderly people, such as cardiovascular diseases, diabetes, low cognitive function, depression, and obesity, were extensively investigated. DNA was isolated from blood cells, amplified by PCR, and digested with Fnu4HI. in this population the frequency of the His allele was 0.056 and the genotypes were distributed according to Hardy-Weinberg equilibrium. Logistic regression analysis showed a significant association between the presence of His allele and cerebrovascular disease and/or transitory ischemic attack (odds ratio) (OR = 3.070, P = 0.027), obesity (OR = 2.241, P = 0.047), and depression (OR = 2.879, P = 0.005). This study indicates that the presence of the rare allele in elderly people can play a significant role in the occurrence of multifactorial diseases. This is the first study analyzing this polymorphism in elderly people in Brazil. More studies should be encouraged to elucidate the mechanisms involved in these diseases. (c) 2005 Wiley-Liss, Inc. en
dc.format.extent 65-68
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof American Journal of Medical Genetics Part B-neuropsychiatric Genetics
dc.rights Acesso restrito
dc.subject elderly population en
dc.subject APOA-IV : 360 en
dc.subject polymorphism en
dc.subject morbidities en
dc.subject apolipoprotein A-IV en
dc.title Association of the apolipoprotein A-IV : 360 Gln/His polymorphism with cerebrovascular disease, obesity, and depression in a Brazilian elderly population en
dc.type Artigo
dc.rights.license http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Dept Morfol, Disciplina Genet, BR-04023900 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Dept Clin Med, Disciplina Geriatria, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Dept Morfol, Disciplina Genet, BR-04023900 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Dept Clin Med, Disciplina Geriatria, São Paulo, Brazil
dc.identifier.doi 10.1002/ajmg.b.30175
dc.description.source Web of Science
dc.identifier.wos WOS:000228759500013



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