Increased blood pressure in the offspring of diabetic mothers

Increased blood pressure in the offspring of diabetic mothers

Author Wichi, Rogerio B. Autor UNIFESP Google Scholar
Souza, Silvia B. Autor UNIFESP Google Scholar
Casarini, Dulce E. Autor UNIFESP Google Scholar
Morris, Mariana Google Scholar
Barreto-Chaves, Maria Luiza Google Scholar
Irigoyen, Maria Claudia Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Wright State Univ
Abstract Studies were conducted in rats to determine the effect of maternal diabetes and the consequent hyperglycemia on cardiovascular function in the offspring. Diabetes was induced in pregnant Wistar rats through streptozotocin injection ( 50 mg/kg). Cardiovascular parameters were measured in 2-mo-old offspring animals of diabetic ( OD, n = 12) and control rats (OC, n = 8). Arterial pressure (AP), heart rate (HR), baroreflex sensitivity, and vascular responsiveness to phenylephrine (PH) and sodium nitroprusside (SN) were measured. Angiotensin-converting enzyme ( ACE) activity in heart, kidney, and lung was determined. OD rats exhibited increases in systolic AP ( 138 +/- 8 vs. 119 +/- 6 mmHg, OD vs. OC), with no change in HR ( 342 +/- 21 vs. 364 +/- 39 beats per minute (bpm), OD vs. OC). the reflex tachycardia elicited by SN was reduced in OD rats, as indicated by the slope of the linear regression ( - 2.2 +/- 0.4 vs. - 3.6 +/- 0.8 bpm/mmHg, OD vs. OC). Vascular responsiveness to PH was increased 63% in OD rats compared with OC. OD rats showed increases in ACE activity in heart, kidney, and lung (1.13 +/- 0.24, 3.04 +/- 0.86, 40.8 +/- 8.9 vs. 0.73 +/- 0.19, 1.7 +/- 0.45, 28.1 +/- 6 nmol His-Leu center dot min(-1) mg protein(-1), OD vs. OC). Results suggest that diabetes during pregnancy affects cardiovascular function in offspring, seen as hypertension, baroreflex dysfunction, and activation of tissue renin-angiotensin system.
Keywords cardiovascular
heart rate
development
angiotensin-converting enzyme
renin-angiotensin system
hyperglycemia
Language English
Date 2005-05-01
Published in American Journal of Physiology-regulatory Integrative and Comparative Physiology. Bethesda: Amer Physiological Soc, v. 288, n. 5, p. R1129-R1133, 2005.
ISSN 0363-6119 (Sherpa/Romeo, impact factor)
Publisher Amer Physiological Soc
Extent R1129-R1133
Origin http://dx.doi.org/10.1152/ajpregu.00366.2004
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000228264500009
URI http://repositorio.unifesp.br/handle/11600/28269

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