The multitude of targets for the immune system and drug therapy in the fungal cell wall

The multitude of targets for the immune system and drug therapy in the fungal cell wall

Author Nimrichter, L. Google Scholar
Rodrigues, M. L. Google Scholar
Rodrigues, E. G. Google Scholar
Travassos, L. R. Google Scholar
Institution Universidade Federal do Rio de Janeiro (UFRJ)
Universidade Federal de São Paulo (UNIFESP)
Abstract Recent studies on fungi revealed that several cytosolic and membrane components migrate to the cell wall together with secreted proteins and biosynthetic polysaccharides to build a dynamic immunoreactive structure. New aspects of fungal cell wall assembly and biosynthesis, focusing on the potential of glycolipids, melanin, heat-shock proteins, historic and surface antigens as targets of drugs and antifungal anti-bodies are discussed. (c) 2005 Elsevier SAS. All rights reserved.
Keywords antifungal therapy
antimicrobial antibodies
fungal cell walls
unfamiliar components
Language English
Date 2005-04-01
Published in Microbes and Infection. Amsterdam: Elsevier B.V., v. 7, n. 4, p. 789-798, 2005.
ISSN 1286-4579 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 789-798
Origin http://dx.doi.org/10.1016/j.micinf.2005.03.002
Access rights Closed access
Type Review
Web of Science ID WOS:000229534600026
URI http://repositorio.unifesp.br/handle/11600/28217

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