Cellular immune response of humans to the circumsporozoite protein of Plasmodium vivax

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dc.contributor.author Rodrigues, Mauricio Martins [UNIFESP]
dc.contributor.author Dutra, Araripe P.
dc.contributor.author Yoshida, Nobuko [UNIFESP]
dc.date.accessioned 2015-06-14T13:24:21Z
dc.date.available 2015-06-14T13:24:21Z
dc.date.issued 1991-06-01
dc.identifier http://dx.doi.org/10.1590/S0074-02761991000200003
dc.identifier.citation Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 86, n. 2, p. 153-158, 1991.
dc.identifier.issn 0074-0276
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/281
dc.description.abstract The cellular immune response to the circumsporozoite (CS) protein of plasmodium vivax of individuals from malaria-endemic areas of Brazil was studied. We examined the in vitro proliferative response of the peripheral blood mononuclear cells (PBMC) of 22 individuals when stimulated with a CS recombinant protein (rPvCS-2) and two other synthetic peptides based on the sequenceof the P. vivax CS protein. Seven of the individuals from malaria-endemic area displayed an antigen specific in vitro proliferative responseto the recombinant protein PvCS-2 and one out of 6, proliferative response to the peptide 308-320. In contrast, none of the individuals displayed a proliferative reponse when stimulated with the D/A peptide which represent some of the repeated units present in this CS protein. Our study, therefore, provides evidence for the presence, withinthe major surface antigen of P. vivax sporozoites, of epitopes capble to induce proliferation of human PBMC. en
dc.format.extent 153-158
dc.language.iso eng
dc.publisher Instituto Oswaldo Cruz, Ministério da Saúde
dc.relation.ispartof Memórias do Instituto Oswaldo Cruz
dc.rights Acesso aberto
dc.subject circumsporozoite protein en
dc.subject sporozoite immunity en
dc.subject malaria en
dc.subject T cell epitopes en
dc.title Cellular immune response of humans to the circumsporozoite protein of Plasmodium vivax en
dc.type Artigo
dc.contributor.institution New York University Department of Medical and Molecular Parasitology
dc.contributor.institution Superintendência de Controle de Endemias
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation New York University Department of Medical and Molecular Parasitology
dc.description.affiliation Superintendência de Controle de Endemias
dc.description.affiliation Escola Paulista de Medicina Disciplina de Parasitologia
dc.description.affiliationUnifesp UNIFESP, EPM, Disciplina de Parasitologia
dc.identifier.file S0074-02761991000200003.pdf
dc.identifier.scielo S0074-02761991000200003
dc.identifier.doi 10.1590/S0074-02761991000200003
dc.description.source SciELO
dc.identifier.wos WOS:A1991GB98100003



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