Cellular immune response of humans to the circumsporozoite protein of Plasmodium vivax

Cellular immune response of humans to the circumsporozoite protein of Plasmodium vivax

Author Rodrigues, Mauricio Martins Autor UNIFESP Google Scholar
Dutra, Araripe P. Google Scholar
Yoshida, Nobuko Autor UNIFESP Google Scholar
Institution New York University Department of Medical and Molecular Parasitology
Superintendência de Controle de Endemias
Universidade Federal de São Paulo (UNIFESP)
Abstract The cellular immune response to the circumsporozoite (CS) protein of plasmodium vivax of individuals from malaria-endemic areas of Brazil was studied. We examined the in vitro proliferative response of the peripheral blood mononuclear cells (PBMC) of 22 individuals when stimulated with a CS recombinant protein (rPvCS-2) and two other synthetic peptides based on the sequenceof the P. vivax CS protein. Seven of the individuals from malaria-endemic area displayed an antigen specific in vitro proliferative responseto the recombinant protein PvCS-2 and one out of 6, proliferative response to the peptide 308-320. In contrast, none of the individuals displayed a proliferative reponse when stimulated with the D/A peptide which represent some of the repeated units present in this CS protein. Our study, therefore, provides evidence for the presence, withinthe major surface antigen of P. vivax sporozoites, of epitopes capble to induce proliferation of human PBMC.
Keywords circumsporozoite protein
sporozoite immunity
malaria
T cell epitopes
Language English
Date 1991-06-01
Published in Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 86, n. 2, p. 153-158, 1991.
ISSN 0074-0276 (Sherpa/Romeo, impact factor)
Publisher Instituto Oswaldo Cruz, Ministério da Saúde
Extent 153-158
Origin http://dx.doi.org/10.1590/S0074-02761991000200003
Access rights Open access Open Access
Type Article
Web of Science ID WOS:A1991GB98100003
SciELO ID S0074-02761991000200003 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/281

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