Effects of chronic anabolic steroid treatment on tonic and reflex cardiovascular control in male rats

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dc.contributor.author Beutel, A.
dc.contributor.author Bergamaschi, C. T.
dc.contributor.author Campos, R. R.
dc.date.accessioned 2016-01-24T12:37:34Z
dc.date.available 2016-01-24T12:37:34Z
dc.date.issued 2005-01-01
dc.identifier http://dx.doi.org/10.1016/j.jsbmb.2004.11.003
dc.identifier.citation Journal of Steroid Biochemistry and Molecular Biology. Oxford: Pergamon-Elsevier B.V., v. 93, n. 1, p. 43-48, 2005.
dc.identifier.issn 0960-0760
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/28083
dc.description.abstract The aim of this study was to analyze the cardiovascular effects of chronic stanozolol administration in male rats. the rats were randomly assigned to one of three groups: (1) control (n=12), (2) chronic treatment with low dose of stanozolol (LD, n = 18, 5 mg/kg week) and; (3) treatment with high dose of stanozolol (HD, n = 28, 20 mg/kg week). Mean arterial pressure (MAP) was higher in both HD (128 +/- 2.2 mmHg) and LD (126 +/- 2.5 mmHg) than control (116 2 mmHg). the LD group showed an increase in cardiac output (control 121 +/- 2.5, LD 154 +/- 5.9 ml/min), whereas in the HD group total peripheral resistance increased (control 1.03 +/- 0.07, HD 1.26 +/- 0.07 mmHg/ml/min). Acute sympathetic blockade caused a similar decrease in MAP in all groups. in conscious rats, the baroreflex index for bradyeardia (control -3.7 +/- 0.4, LD -2.0 +/- 0.1 beat/mmHg) and tachycardia (control -3.6 +/- 0.3, LD -4.7 +/- 0.2 beat/mmHg) responses changed only in the LD group. Cardiac hypertrophy was observed in both treated groups (P < 0.05). in conclusion, hypertension with differential hemodynamic changes and alterations in the reflex control in heart rate is seen at different stanozolol doses, which may be important variables in the cardiovascular effects of anabolic steroids. (c) 2004 Elsevier B.V. All rights reserved. en
dc.format.extent 43-48
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Journal of Steroid Biochemistry and Molecular Biology
dc.rights Acesso restrito
dc.subject baroreflex en
dc.subject hypertrophy en
dc.subject blood pressure en
dc.subject cardiac output en
dc.subject stanozolol en
dc.title Effects of chronic anabolic steroid treatment on tonic and reflex cardiovascular control in male rats en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Paulista Sch Med, Dept Physiol, São Paulo, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Paulista Sch Med, Dept Physiol, São Paulo, SP, Brazil
dc.identifier.doi 10.1016/j.jsbmb.2004.11.003
dc.description.source Web of Science
dc.identifier.wos WOS:000227933000005



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