Effects of morphine or naloxone on cocaine-induced genital reflexes in paradoxical sleep-deprived rats

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dc.contributor.author Andersen, M. L.
dc.contributor.author Frussa-Filho, R.
dc.contributor.author Tufik, S.
dc.date.accessioned 2016-01-24T12:37:28Z
dc.date.available 2016-01-24T12:37:28Z
dc.date.issued 2004-11-01
dc.identifier http://dx.doi.org/10.1016/j.pbb.2004.09.003
dc.identifier.citation Pharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 79, n. 3, p. 515-521, 2004.
dc.identifier.issn 0091-3057
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/28010
dc.description.abstract The involvement of opioidergic neurotransmission in the modulation of genital reflexes induced by paradoxical sleep deprivation (PSD) and cocaine in rats was the aim of the present study. Morphine (0, 1, 5 and 10 mg/kg) and naloxone (0, 0.3, 3 and 30 mg/kg) were administered prior to saline or cocaine to rats that had been deprived of sleep and the incidence of penile erections (PE) and ejaculations (EJ) was measured. PSD alone induced PE in 50% and EJ in 20% of the rats, but these behaviors were not influenced by morphine or naloxone. Cocaine potentiated the incidence of genital reflexes in PSD rats to 90% (PE) and 70% (EJ). Morphine and not naloxone significantly reduced the percentage of rats displaying this response at the highest doses. Morphine also significantly reduced PE and EJ frequencies at 10 mg/kg. Furthermore, this inhibitory effect of morphine on genital reflexes was prevented by the prior injection of naloxone. Although a number of factors are involved in such a complex phenomenon as PE and EJ, our data show that activation of the opioidergic systems by the agonist morphine reduces genital reflexes-induced by cocaine in PSD males while the antagonist, naloxone, did not have any significant effect. the findings suggest that the stimulating effects of cocaine in potentiating genital reflexes in PSD rats can be unidirectionally modified by opioidergic systems. (C) 2004 Elsevier Inc. All rights reserved. en
dc.format.extent 515-521
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Pharmacology Biochemistry and Behavior
dc.rights Acesso restrito
dc.subject sleep deprivation en
dc.subject genital reflexes en
dc.subject morphine en
dc.subject naloxone en
dc.subject opioid en
dc.subject cocaine en
dc.subject sexual behavior en
dc.subject rat en
dc.title Effects of morphine or naloxone on cocaine-induced genital reflexes in paradoxical sleep-deprived rats en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Pharmacol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Pharmacol, BR-04024002 São Paulo, Brazil
dc.identifier.doi 10.1016/j.pbb.2004.09.003
dc.description.source Web of Science
dc.identifier.wos WOS:000225871200013



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