Maternal KIR repertoire is not associated with recurrent spontaneous abortion

Maternal KIR repertoire is not associated with recurrent spontaneous abortion

Author Witt, C. S. Google Scholar
Goodridge, J. Google Scholar
Gerbase-DeLima, Maria Autor UNIFESP Google Scholar
Daher, Silvia Autor UNIFESP Google Scholar
Christiansen, F. T. Google Scholar
Institution Royal Perth Hosp
Univ W Australia
Universidade Federal de São Paulo (UNIFESP)
Abstract Background: in view of evidence suggesting an immunological cause of recurrent spontaneous abortions (RSA) and the large number of maternal natural killer (NK) cells present in the pregnant uterus, we investigated the genetic polymorphism of the killer cell immunoglobulin-like receptors (KIR) in women with RSA. Methods: KIR gene repertoire and KIR2DL4 (a receptor for HLA-G) genotyping were determined by SSP and SSCP respectively, in women experiencing RSA and controls. Results: the KIR repertoire did not differ between RSA patients and controls in terms of: (i) the number of inhibitory receptors; (ii) the number of activating receptors; (iii) the ratio of inhibitory to activating receptors. KIR2DL4, a receptor for HLA-G, has different transmembrane alleles, which produce functionally different phenotypes. the frequency of KIR2DL4 transmembrane genotypes differed significantly between RSA patients and controls (P=0.03). However, although homozygosity for a membrane-bound receptor was more frequent in patients (25%) than controls (10%), other genotypes that would produce the same phenotype were not more frequent in patients than controls. Conclusions: the data provide little evidence that KIR polymorphism plays a role in predisposition to RSA.
Keywords killer cell immunoglobulin-like receptors
NK cell
recurrent spontaneous abortion
Language English
Date 2004-11-01
Published in Human Reproduction. Oxford: Oxford Univ Press, v. 19, n. 11, p. 2653-2657, 2004.
ISSN 0268-1161 (Sherpa/Romeo, impact factor)
Publisher Oxford Univ Press
Extent 2653-2657
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000224703500035

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