Levodopa effect upon functional balance of Parkinson's disease patients

Levodopa effect upon functional balance of Parkinson's disease patients

Author Nova, I. C. Google Scholar
Perracini, M. R. Google Scholar
Ferraz, H. B. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective. the aim of this study was to evaluate functional balance in PD patients taking levodopa during their 'on' and 'off' phases.Design. We evaluated 23 PD patients who were manifesting fluctuations of levodopa effect. All patients were assessed by Hoehn-Yahr, UPDRS-III and Schwab-England rating scales and by the Berg functional balance scale during a practically defined 'off' (at least after 12 h the last levodopa intake) and 'on' (the mobile state induced by the drug) phases.Results. Mean scores obtained for all scales showed improvements during the 'on' phase of levodopa and all of the comparisons were statistically significant. Mean scores of Berg scale moved from 31.7 during the 'off' phase to 42.7 during the 'on' phase. Mean UPDRS 'off' and 'on' scores were 50.6 and 32.0, respectively.Conclusion. We conclude that Berg functional balance scale is able to detect changes in balance and that levodopa can modify the postural instability of PD patients. (C) 2004 Elsevier B.V. All rights reserved.
Keywords Parkinson's disease
levodopa
postural instability
balance berg functional balance scale
Language English
Date 2004-10-01
Published in Parkinsonism & Related Disorders. Oxford: Elsevier B.V., v. 10, n. 7, p. 411-415, 2004.
ISSN 1353-8020 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 411-415
Origin http://dx.doi.org/10.1016/j.parkreldis.2004.04.004
Access rights Closed access
Type Article
Web of Science ID WOS:000224607900004
URI http://repositorio.unifesp.br/handle/11600/27966

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