Diurnal variation in the genital reflexes and hormone levels induced by paradoxical sleep deprivation and cocaine in male rats

Diurnal variation in the genital reflexes and hormone levels induced by paradoxical sleep deprivation and cocaine in male rats

Author Andersen, M. L. Google Scholar
Papale, L. A. Google Scholar
Tufik, S. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The purpose was to ascertain whether the genital reflexes induced by paradoxical sleep deprivation (PSD) in male rats show diurnal variation, and whether the hormonal rhythm of testosterone and progesterone is involved in these behaviors. Genital reflexes (penile erection - PE, and ejaculation - EJ) and hormone levels were assessed during a 24 h period at four testing times (0900, 1600, 2 100 and 0400 h) in PSD rats injected with saline or cocaine. Results indicated that PE in PSD rats given saline or cocaine did not show diurnal variation while EJ responses were significantly reduced at 0400 h in the PSD-cocaine group. the home-cage control group testosterone concentrations were lower at 1600, 2100 and 0400 h than at 0900 h. At 0900 h, testosterone levels were significantly lower in the PSD groups than in the control group. in contrast, progesterone levels were significantly higher in PSD groups in relation to the control group at the four testing times. Thus, we observed strong diurnal variation in testosterone and progesterone in control rats whereas only EJ responses in PSD-cocaine seemed to be influenced by the time of day. These results suggest that progesterone may influence the modulation of male genital reflexes displayed by sleep-deprived rats. (C) 2004 Elsevier Inc. All rights reserved.
Keywords sleep
drug of abuse
sexual behavior
testosterone
progesterone
Language English
Date 2004-09-30
Published in Brain Research Bulletin. Oxford: Pergamon-Elsevier B.V., v. 64, n. 3, p. 215-220, 2004.
ISSN 0361-9230 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 215-220
Origin http://dx.doi.org/10.1016/j.brainresbull.2004.07.007
Access rights Closed access
Type Article
Web of Science ID WOS:000224523200003
URI http://repositorio.unifesp.br/handle/11600/27943

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