Low ethanol concentrations selectively augment the tonic inhibition mediated by delta subunit-containing GABA(A) receptors in hippocampal neurons

Low ethanol concentrations selectively augment the tonic inhibition mediated by delta subunit-containing GABA(A) receptors in hippocampal neurons

Author Wei, Weizheng Z. Google Scholar
Faria, Leonardo Coutinho Autor UNIFESP Google Scholar
Mody, Istvan Google Scholar
Institution Univ Calif Los Angeles
Universidade Federal de São Paulo (UNIFESP)
Abstract In central neurons, a tonic conductance is activated by ambient levels of the inhibitory transmitter GABA. Here, we show that in dentate gyrus granule cells, where tonic inhibition is mediated by delta subunit-containing GABA(A) receptors, this conductance is augmented by low concentrations (30 mM) of ethanol. in contrast, the tonic inhibition mediated by alpha5 subunit-containing receptors of CA1 pyramidal cells is not affected. the effect of ethanol on tonic inhibition specifically reduces the excitability of the dentate gyrus and identifies the delta subunit-dependent tonic inhibition as a likely site of ethanol action in the brain.
Keywords alcohol
CA1
dentate
GABA
hippocampus
inhibition
Language English
Date 2004-09-22
Published in Journal of Neuroscience. Washington: Soc Neuroscience, v. 24, n. 38, p. 8379-8382, 2004.
ISSN 0270-6474 (Sherpa/Romeo, impact factor)
Publisher Soc Neuroscience
Extent 8379-8382
Origin http://dx.doi.org/10.1523/JNEUROSCI.2040-04.2004
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000224009600020
URI http://repositorio.unifesp.br/handle/11600/27942

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