Treatment of pediatric myelodysplastic syndromes and juvenile myelomonocytic leukemia: the Brazilian experience in the past decade

Treatment of pediatric myelodysplastic syndromes and juvenile myelomonocytic leukemia: the Brazilian experience in the past decade

Author Valera, E. T. Google Scholar
Latorre, MDD Google Scholar
Mendes, W. L. Google Scholar
Seber, A. Google Scholar
Lee, MLM Google Scholar
Paula, MJA de Google Scholar
Loggetto, SR Google Scholar
Velloso, E. Google Scholar
Niero-Melo, L. Google Scholar
Lopes, L. F. Google Scholar
Brazilian Cooperative Grp Pediat M Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Inst Oncol
Hematol Ctr
Abstract Background: Therapy strategies for myelodysplastic syndromes (MDS) and juvenile myelomonocytic leukemia (JMML) vary considerably. Objective: To review the treatment of Brazilian children who were diagnosed with MDS or JMML in the past decade and reported to the Brazilian Cooperative Group on Pediatric Myelodysplastic syndromes (BCG-MDS-PED). Results: of 173 children reported to the BCG-MDS-PED from January 1997 to January 2003 with a suspected diagnosis of MDS or JMML, 91 had the diagnosis confirmed after central review of the bone marrow aspirate and biopsy. Information on previous treatments was available for 78 MDS/JMML patients. Treatment varied from different schedules of low-dose (14%) and standard-dose chemotherapy (50%), granulocyte-colony-stimulating factor (G-CSF 7%), interferon (5%), steroids (2%) and erythropoietin (2%) to allogeneic stem-cell transplantation (SCT) (14%). No survival advantage could be demonstrated based on Hasle's classification or based on treatment. Conclusion: This report reflects the current practice in treating Brazilian children with MDS/JMML without specific Cooperative Group guidelines. Treatment modalities were very heterogeneous. the strategies for implementing a national protocol should consider international guidelines and focus on local experience and available resources. (C) 2004 Elsevier B.V. All rights reserved.
Keywords myelodysplastic syndromes
children
treatment
neoplasm
Language English
Date 2004-09-01
Published in Leukemia Research. Oxford: Pergamon-Elsevier B.V., v. 28, n. 9, p. 933-939, 2004.
ISSN 0145-2126 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 933-939
Origin http://dx.doi.org/10.1016/j.leukres.2004.01.008
Access rights Closed access
Type Article
Web of Science ID WOS:000222820200008
URI http://repositorio.unifesp.br/handle/11600/27919

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