Ditterential effects of spontaneous versus forced exercise in rats on the staining of parvalbumin-positive neurons in the hippocampal formation

Ditterential effects of spontaneous versus forced exercise in rats on the staining of parvalbumin-positive neurons in the hippocampal formation

Author Arida, R. M. Google Scholar
Scorza, C. A. Google Scholar
Silva, A. V. da Google Scholar
Scorza, F. A. Google Scholar
Cavalheiro, E. A. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
UMC
Abstract To investigate whether the type of physical activity, voluntary or forced, would promote different morphological changes in hippocampal formation we performed an immunocytochemical study using the parvalbumin (PV) distribution as a marker. Animals submitted to the voluntary exercise were placed in a voluntary wheel running and those submitted to the forced exercise were placed in a motor driven treadmill. Both exercise groups were submitted to 10 consecutive days of physical activity. It was observed a higher number of PV-positive cells in the hilus of dentate gyrus (DG) in the voluntary and forced exercise groups when compared to the control group. the voluntary exercise group also presented a stronger fiber staining in the DG hilus than the forced exercise and control groups. in contrast, no differences were found in the pattern of PV staining in CA1/CA3 region between exercise and control groups. These findings demonstrate that physical activity leads to prominent plastic changes in the hippocampal formation of rats that were more evident following voluntary activity. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
Keywords parvalbumin
physical exercise
voluntary wheel running
treadmill
brain
Language English
Date 2004-07-08
Published in Neuroscience Letters. Clare: Elsevier Sci Ireland Ltd, v. 364, n. 3, p. 135-138, 2004.
ISSN 0304-3940 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 135-138
Origin http://dx.doi.org/10.1016/j.neulet.2004.03.086
Access rights Closed access
Type Article
Web of Science ID WOS:000222289700001
URI http://repositorio.unifesp.br/handle/11600/27837

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