Stavudine effects on rat pregnancy outcome

Show simple item record Barreto, RLB Simoes, M. D. Amed, A. M. Soares, J. M. Oliveira, R. M. Kulay, L. 2016-01-24T12:37:12Z 2016-01-24T12:37:12Z 2004-06-01
dc.identifier.citation Journal of Obstetrics and Gynaecology Research. Carlton: Blackwell Publishing Asia, v. 30, n. 3, p. 242-245, 2004.
dc.identifier.issn 1341-8076
dc.description.abstract Objective: Stavudine is an inhibitor of HIV reverse transcriptase and acts as a chain terminator during DNA synthesis. the aim of the study presented here was to evaluate the effects of stavudine during rat pregnancy.Methods: Female rats were randomly divided into four treatment groups: GI (treated with the drug vehicle); GII; GIII; and GIV (treated with 1, 3 or 9 mg/kg of stavudine, respectively) (n = 25 pregnant rats for every group). Rats were treated by gavage once daily. the treatment period extended from day 0 until the 20th day of pregnancy. Body weights were recorded weekly during this period. At term, the rats were sacrificed, and the implantation sites and number of fetuses and resorptions were recorded. the fetuses were evaluated for external abnormalities under a stereomicroscope.Results: No differences in body weight gain between the groups were observed. the mean number of implantations per dam in stavudine-treated groups was higher than in the control group (P < 0.05); however, only GIII presented an increase in the mean number of resorptions compared to the other groups (P < 0.01). the resorption/implantation rate was higher in the GII group and lower in the GIV group as compared to the other groups. Neither the mean fetal weights nor the placental weights differed significantly among the groups. No external anomalies were observed at dissection in rat fetuses, placentae or uteri.Conclusion: Rat pregnancy outcome seems to be affected by stavudine, mainly with respect to the mechanisms of intrauterine concept survival. en
dc.format.extent 242-245
dc.language.iso eng
dc.publisher Blackwell Publishing Asia
dc.relation.ispartof Journal of Obstetrics and Gynaecology Research
dc.rights Acesso restrito
dc.subject antiretroviral drugs en
dc.subject fetal resorption en
dc.subject pregnancy en
dc.subject rat en
dc.subject stavudine en
dc.title Stavudine effects on rat pregnancy outcome en
dc.type Artigo
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Oeste Paulista, Sch Med, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Sch Med, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Inst Biomed Sci, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Sch Med, São Paulo, Brazil
dc.identifier.doi 10.1111/j.1447-0756.2004.00180.x
dc.description.source Web of Science
dc.identifier.wos WOS:000221301400014


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