The C-terminus of murine S100A9 inhibits hyperalgesia and edema induced by jararhagin

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dc.contributor.author Dale, C. S.
dc.contributor.author Goncalves, LRC
dc.contributor.author Juliano, L.
dc.contributor.author Juliano, M. A.
dc.contributor.author Silva, AMM da
dc.contributor.author Giorgi, R.
dc.date.accessioned 2016-01-24T12:34:12Z
dc.date.available 2016-01-24T12:34:12Z
dc.date.issued 2004-01-01
dc.identifier http://dx.doi.org/10.1016/j.peptides.2003.12.008
dc.identifier.citation Peptides. New York: Elsevier B.V., v. 25, n. 1, p. 81-89, 2004.
dc.identifier.issn 0196-9781
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/27547
dc.description.abstract The effect of a synthetic peptide (H-92-G(110)) identical to the C-terminus of murine S100A9 (mS100A9p) was investigated on hyperalgesia and edema induced by either jararhagin or papain in the rat paw. mS100A9p not only reverted hyperalgesia and edema induced by jararhagin, but also the highest concentration induced antinociception. Hemorrhage induced by jararhagin and its hydrolytic activity were inhibited by mS100A9p. These data suggest that mS100A9p might block jararhagin-induced hyperalgesia and edema by inhibiting jararhagin catalytic activity, since papain-induced hyperalgesia and edema were not inhibited by mS100A9p. (C) 2004 Elsevier Inc. All rights reserved. en
dc.format.extent 81-89
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Peptides
dc.rights Acesso restrito
dc.subject hyperalgesia en
dc.subject edema en
dc.subject jararhagin en
dc.subject papain en
dc.subject MRP-14 en
dc.subject S100A9 en
dc.title The C-terminus of murine S100A9 inhibits hyperalgesia and edema induced by jararhagin en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Butantan Inst
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Butantan Inst, Lab Pathophysiol, BR-05503900 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Inst Pharmacol, Dept Biophys, BR-04044020 São Paulo, Brazil
dc.description.affiliation Butantan Inst, Immunopathol Lab, BR-05503900 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Inst Pharmacol, Dept Biophys, BR-04044020 São Paulo, Brazil
dc.identifier.doi 10.1016/j.peptides.2003.12.008
dc.description.source Web of Science
dc.identifier.wos WOS:000220267900011



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