The C-terminus of murine S100A9 inhibits hyperalgesia and edema induced by jararhagin

The C-terminus of murine S100A9 inhibits hyperalgesia and edema induced by jararhagin

Author Dale, C. S. Google Scholar
Goncalves, LRC Google Scholar
Juliano, L. Google Scholar
Juliano, M. A. Google Scholar
Silva, AMM da Google Scholar
Giorgi, R. Google Scholar
Institution Butantan Inst
Universidade Federal de São Paulo (UNIFESP)
Abstract The effect of a synthetic peptide (H-92-G(110)) identical to the C-terminus of murine S100A9 (mS100A9p) was investigated on hyperalgesia and edema induced by either jararhagin or papain in the rat paw. mS100A9p not only reverted hyperalgesia and edema induced by jararhagin, but also the highest concentration induced antinociception. Hemorrhage induced by jararhagin and its hydrolytic activity were inhibited by mS100A9p. These data suggest that mS100A9p might block jararhagin-induced hyperalgesia and edema by inhibiting jararhagin catalytic activity, since papain-induced hyperalgesia and edema were not inhibited by mS100A9p. (C) 2004 Elsevier Inc. All rights reserved.
Keywords hyperalgesia
edema
jararhagin
papain
MRP-14
S100A9
Language English
Date 2004-01-01
Published in Peptides. New York: Elsevier B.V., v. 25, n. 1, p. 81-89, 2004.
ISSN 0196-9781 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 81-89
Origin http://dx.doi.org/10.1016/j.peptides.2003.12.008
Access rights Closed access
Type Article
Web of Science ID WOS:000220267900011
URI http://repositorio.unifesp.br/handle/11600/27547

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