Evaluation of acute administration of natural products with potential diuretic effects, in humans

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dc.contributor.author Laranja, Sandra Maria Rodrigues [UNIFESP]
dc.contributor.author Bergamaschi, Cassia Toledo [UNIFESP]
dc.contributor.author Schor, Nestor [UNIFESP]
dc.date.accessioned 2015-06-14T13:24:21Z
dc.date.available 2015-06-14T13:24:21Z
dc.date.issued 1991-01-01
dc.identifier http://dx.doi.org/10.1590/S0074-02761991000600053
dc.identifier.citation Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 86, p. 237-240, 1991.
dc.identifier.issn 0074-0276
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/273
dc.description.abstract In order to evaluate the potential diuretic effect of two natural products, Elephantopus scaber and Alpinia speciosa, a trial administration was carried out in ten healthy volunteers and the effects compared to the those of a placebo. The substances were given on different days, with a seven day interval between doses. The amount of substance administered to the subjects was five times the usual dose i.e. 7.5 g/100 ml and 0.8 g/100 ml respectively. The following parameters parameteres were measured: urinary and plasma sodium, potassium, uric acid, calcium, phosphate, urea, creatinine. The subjects were also examined clinically and total urinary volume was assessed. The only significant finding (p < 0.05) was a slight diuresis with Alpinia speciosa, which also lowered the diastolic (p < 0.05) and systolic (p < 0.01) blood pressures. No effect on electrolytes or renal function parameters was observed, and this probably excludes any renal tubular or glomerular effect from these substances. en
dc.format.extent 237-240
dc.language.iso eng
dc.publisher Instituto Oswaldo Cruz, Ministério da Saúde
dc.relation.ispartof Memórias do Instituto Oswaldo Cruz
dc.rights Acesso aberto
dc.subject Natural products en
dc.subject diuretics en
dc.subject Elephantopus scaber en
dc.subject Alpinia speciosa en
dc.title Evaluation of acute administration of natural products with potential diuretic effects, in humans en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Escola Paulista de Medicina Disciplina de Nefrologia
dc.description.affiliationUnifesp UNIFESP, EPM, Disciplina de Nefrologia
dc.identifier.file S0074-02761991000600053.pdf
dc.identifier.scielo S0074-02761991000600053
dc.identifier.doi 10.1590/S0074-02761991000600053
dc.description.source SciELO
dc.identifier.wos WOS:A1991GN58900053


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