Tonin in rat heart with experimental hypertrophy

Tonin in rat heart with experimental hypertrophy

Author Borges, J. C. Google Scholar
Silva, J. A. Google Scholar
Gomes, M. A. Google Scholar
Lomez, ESL Google Scholar
Leite, K. M. Google Scholar
Araujo, R. C. Google Scholar
Bader, M. Google Scholar
Pesquero, J. B. Google Scholar
Pesquero, J. L. Google Scholar
Institution Universidade Federal de Minas Gerais (UFMG)
Universidade Federal de São Paulo (UNIFESP)
Univ Mogi das Cruzes
Max Delbruck Ctr Mol Med
Abstract The present study was undertaken to determine tonin expression and activity in rat heart presenting isoproterenol-induced hypertrophy. Renin, angiotensin-converting enzyme (ACE), and angiotensinogen (AG) expression were also determined. Wistar rats were treated with isoproterenol for 7 days (5 mg.kg(-1).day(-1) sc). for untreated animals, the levels of tonin-specific activity in the atrium were 2.6- and 5.5-fold higher than those of the left and right ventricle, respectively. After treatment, the levels of tonin-specific activity increased twofold in the atrium but did not change in the ventricles. Renin expression was not detectable in these structures, and ACE expression levels did not change with treatment. AG expression was detected in the left ventricle at very low levels compared with the atrium and increased significantly only in the hypertrophied atrium (1.8-fold). Tonin mRNA was not detected in the ventricle but was found at low levels in the atrium, which increased after isoproterenol treatment. Our results permit us to conclude that tonin may play a role in the process of heart hypertrophy in the rat.
Keywords angiotensin II
isoproterenol
growth myocardium
renin
angiotensinogen
Language English
Date 2003-06-01
Published in American Journal of Physiology-heart and Circulatory Physiology. Bethesda: Amer Physiological Soc, v. 284, n. 6, p. H2263-H2268, 2003.
ISSN 0363-6135 (Sherpa/Romeo, impact factor)
Publisher Amer Physiological Soc
Extent H2263-H2268
Origin http://dx.doi.org/10.1152/ajpheart.00416.2002
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000182810000047
URI http://repositorio.unifesp.br/handle/11600/27264

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