Cocaine-induced genital reflexes during paradoxical sleep deprivation and recovery

Cocaine-induced genital reflexes during paradoxical sleep deprivation and recovery

Author Andersen, M. L. Google Scholar
Bignotto, M. Google Scholar
Tufik, S. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Paradoxical sleep deprivation (PSD) for 96 h together with cocaine administration elicits genital reflexes (penile erection [PE] and ejaculation [EJ]) in rats. Our objective was to examine genital reflexes after periods of 24, 48, 72, 96, 120, and 144 h of PSD and during a 4-day recovery period in acute cocaine-administered rats. After 24 h of PSD followed by cocaine administration, animals started to display PE and EJ, peaking in the 96th It of PSD, whereas PE and EJ were absent in control animals. the effects of more than 96 h of PSD decrease genital reflexes as observed after 120 and 144 h. Genital reflexes were present in the recovery periods but diminished gradually during the period evaluated. Even short periods of PSD probably cause supersensitivity of dopamine (DA) receptors and exacerbate the effects of cocaine on dopaminergic pathways to induce frequent PE and EJ. (C) 2002 Elsevier Science Inc. All rights reserved.
Keywords paradoxical sleep deprivation
recovery
cocaine
sexual behavior
dopamine
rats
Language English
Date 2003-02-01
Published in Physiology & Behavior. Oxford: Pergamon-Elsevier B.V., v. 78, n. 2, p. 255-259, 2003.
ISSN 0031-9384 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 255-259
Origin http://dx.doi.org/10.1016/S0031-9384(02)00972-1
Access rights Closed access
Type Article
Web of Science ID WOS:000181146200010
URI http://repositorio.unifesp.br/handle/11600/27130

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