Antimicrobial susceptibility patterns of unusual nonfermentative gram-negative bacilli isolated from Latin America: report from the SENTRY Antimicrobial Surveillance Program (1997-2002)

Antimicrobial susceptibility patterns of unusual nonfermentative gram-negative bacilli isolated from Latin America: report from the SENTRY Antimicrobial Surveillance Program (1997-2002)

Author Gales, Ana Cristina Autor UNIFESP Google Scholar
Jones, Ronald N Google Scholar
Andrade, Soraya Sgambatti Autor UNIFESP Google Scholar
Sader, Helio Silva Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
JMI Laboratories The Jones Group
Abstract The antimicrobial susceptibility of 176 unusual non-fermentative gram-negative bacilli (NF-GNB) collected from Latin America region through the SENTRY Program between 1997 and 2002 was evaluated by broth microdilution according to the National Committee for Clinical Laboratory Standards (NCCLS) recommendations. Nearly 74% of the NF-BGN belonged to the following genera/species: Burkholderia spp. (83), Achromobacter spp. (25), Ralstonia pickettii (16), Alcaligenes spp. (12), and Cryseobacterium spp. (12). Generally, trimethoprim/sulfamethoxazole (MIC50, < 0.5 µg/ml) was the most potent drug followed by levofloxacin (MIC50, 0.5 µg/ml), and gatifloxacin (MIC50, 1 µg/ml). The highest susceptibility rates were observed for levofloxacin (78.3%), gatifloxacin (75.6%), and meropenem (72.6%). Ceftazidime (MIC50, 4 µg/ml; 83.1% susceptible) was the most active beta-lactam against B. cepacia. Against Achromobacter spp. isolates, meropenem (MIC50, 0.25 µg/ml; 88% susceptible) was more active than imipenem (MIC50, 2 µg/ml). Cefepime (MIC50, 2 µg/ml; 81.3% susceptible), and imipenem (MIC50, 2 µg/ml; 81.3% susceptible) were more active than ceftazidime (MIC50, >16 µg/ml; 18.8% susceptible) and meropenem (MIC50, 8 µg/ml; 50% susceptible) against Ralstonia pickettii. Since selection of the most appropriate antimicrobial agents for testing and reporting has not been established by the NCCLS for many of NF-GNB species, results from large multicenter studies may help to guide the best empiric therapy.
Keywords antimicrobial susceptibility
nonfermentative gram-negative
Latin America
SENTRY
Language English
Date 2005-10-01
Published in Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 100, n. 6, p. 571-577, 2005.
ISSN 0074-0276 (Sherpa/Romeo, impact factor)
Publisher Instituto Oswaldo Cruz, Ministério da Saúde
Extent 571-577
Origin http://dx.doi.org/10.1590/S0074-02762005000600011
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000233085400011
SciELO ID S0074-02762005000600011 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/2705

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