Lower esophageal sphincter reacts against intraabdominal pressure in children with symptoms of gastroesophageal reflux

Lower esophageal sphincter reacts against intraabdominal pressure in children with symptoms of gastroesophageal reflux

Author Goldani, HAS Google Scholar
Fernandes, MIM Google Scholar
Vicente, YAMVA Google Scholar
Dantas, R. O. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Studies of the effect of increased intraabdominal pressure on the lower esophageal sphincter (LES) are controversial. This study aimed to verify the LES competence against extrinsic abdominal compression in children with and without symptoms of gastroesophageal reflux (GER). Eighteen children ages 6-20 months were evaluated, 11 of them with symptoms of GER (group I) and 7 without symptoms of GER (group II). Manometry of the esophagus, LES, and stomach was performed in all children who underwent extrinsic abdominal compressions of 20, 40, 60, and 80 mm Hg. the pressure gradients in the esophagus, LES, and stomach were measured. the pressure gradient showed a significant difference only in the esophagus after extrinsic abdominal compressions of 60 mm Hg [group I median (range): 7.6mm Hg (2.7-20.0) vs group II: 2.8 mm Hg (1.4-9.6), P < 0.05], and 80 mm Hg [group I median (range): 7.7 mm Hg (3.7-28.9) vs group II: 3.8 mm Hg (1.2-21.1), P < 0.05]. It was concluded that the competence of LES to contain increased intraabdominal pressure might be an important factor in the pathophysiology of GER in children.
Keywords gastroesophageal reflux
children
esophageal manometry
common cavity
Language English
Date 2002-11-01
Published in Digestive Diseases and Sciences. New York: Kluwer Academic/plenum Publ, v. 47, n. 11, p. 2544-2548, 2002.
ISSN 0163-2116 (Sherpa/Romeo, impact factor)
Publisher Kluwer Academic/plenum Publ
Extent 2544-2548
Origin http://dx.doi.org/10.1023/A:1020524412847
Access rights Closed access
Type Article
Web of Science ID WOS:000178529100028
URI http://repositorio.unifesp.br/handle/11600/27030

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