Analgesic activity of a triterpene isolated from Scoparia dulcis L. (vassourinha)

Analgesic activity of a triterpene isolated from Scoparia dulcis L. (vassourinha)

Author Freire, Sonia Maria de Farias Google Scholar
Torres, Luce Maria Brandão Autor UNIFESP Google Scholar
Roque, Nidia Franca Google Scholar
Souccar, Caden Autor UNIFESP Google Scholar
Lapa, Antonio José Autor UNIFESP Google Scholar
Institution UFMA Departamento de Fisiologia
UFMA Departamento de Química
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract Analgesic and anti-inflammatory activities of water (WE) and ethanolic (EE) extracts of Scoparia dulcis L. were investigated in rats and mice, and compared to the effects induced by Glutinol, a triterpene isolated by purification of EE. Oral adminsitration (p.o.) of either WE or EE(up to 2 g/Kg) did not alter the normal spontaneous activity of mice and rats. The sleeping time induced by sodium pentobarbital (50 mg/Kg, i.p.) was prolonged by 2 fold in mice pretreated with 0.5 g/Kg EE, p.o. Neither extract altered the tail flick response of mice in immersion test, but previous administration of EE (0.5 g/Kg, p.o.) reduced writhings induced by 0.8% acetic acid (0.1 ml/10 g, i.p.) in mice by 47% EE (0.5 and 1 g/Kg, p.o.) inhibited the paw edema induced by carrageenan in rats by respectively 46% and 58% after 2 h, being ineffective on the paw edema induced by dextran. No significant analgesic or anti-edema effects were detected in animals pretreated with WE (1 g/Kg, p.o.). Administration of Glutinol (30 mg/Kg, p.o.) reduced writhing induced by acetic acid in mice by 40% and the carrageenan induced paw edema in rats by 73%. The results indicate that the analgesic activity of S dulcis L. may be explained by explained by an anti-inflammatory activity probably related to the triterpene Glutinol.
Keywords Scoparia dulcis L
analgesia
anti-inflammatory
medicinal plant
Language English
Date 1991-01-01
Published in Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 86, p. 149-151, 1991.
ISSN 0074-0276 (Sherpa/Romeo, impact factor)
Publisher Instituto Oswaldo Cruz, Ministério da Saúde
Extent 149-151
Origin http://dx.doi.org/10.1590/S0074-02761991000600034
Access rights Open access Open Access
Type Article
Web of Science ID WOS:A1991GN58900034
SciELO ID S0074-02761991000600034 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/270

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